Drug A and drug B are orally administered drugs. Drug A has a pKa of 3.5,...
Drug A and drug B are orally administered drugs. Drug A has a pKa of 3.5, whereas Drug B has a pKa of 8.5. Where will the two drugs be ionized and unionized regarding in stomach and plasma?
Homework Answers
Drug A is a weak acid and is more lipid soluble in acidic solution.weak acid has a high absortion rate in stomach which is highly acidic. Drug B is a weak base is lipid soluble in alkaline solution. weak base is absorbed highly from small intestine.
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Drug A and drug B are orally administered drugs. Drug A has a
pKa of 3.5,...
41. Aspirin (acetylsalicylic acid) has a pKa of 3.5. (1) Calculate the ratio of ionized/unionized of...
41. Aspirin (acetylsalicylic acid) has a pKa of 3.5. (1) Calculate the ratio of ionized/unionized of the drug in the stomach where pH is 1. (i) Calculate the ratio of ionized/unionized in the intestine where pH is 6. (iii) Based on these calculations- where is aspirin absorbed within the body? (15 points) 42. What is oral daily dose for each family member? (10 points) Amount of Amount of Total Body Media Consumed Benzene Consumed Benzene Weight Water Fish Soil Water...
Drug X is a weakly acidic drug that has a pKa of 7.2 a) Calculate the...
Drug X is a weakly acidic drug that has a pKa of 7.2 a) Calculate the percentage of the ionized form of this drug in the duodenum which has a pH of 5.0? explain the concept and the scientific rationale behind your answer. b)if the pH in the stomach is 2 and that in the intestine is 8, in a new line write which of these two GIT parts drug X is maximally absorbed from; the stomach or the intestine?...
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of .........................
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of ...................... is important for the drug that is excreted unchanged. 10. pka is the ................. at which 50% of drugs present in an ionised form. 17. Renal excretion has 3 processes namely ......... .................... and ............... 18. The study of what the body does to the drug is known as ....... 19. Enzyme inducers .................. the effect of other drugs but the enzyme inhibitors ......
13. Aspirin is a common anti-inflammatory medication. A drug dose was administered orally and initial concentration...
13. Aspirin is a common anti-inflammatory medication. A drug dose was administered orally and initial concentration of Aspirin in plasma was 33.2 mg/L. Knowing that Aspirin elimination follows zero order kinetics and drug half-life is 15 min. Determine: How long will it take for a drug concentration to decrease to 5% of its initial value? What is the elimination rate constant?
9. Describe the main differences in drug absorption if it is administered: a) Orally b) Through...
9. Describe the main differences in drug absorption if it is administered: a) Orally b) Through intracerebral injection c) Inhaled (through lungs) In which case peak concentration will be reached faster? In which case drug elimination will occur faster?
please do all parts. thank you so much asap Which drug would be most readily absorbed...
please do all parts. thank you so much
asap
Which drug would be most readily absorbed from the stomach (pH 2.0)? A. Weak acid, pKa 2.0 B. Weak acid, pKa 3.5 C. Weak base, pKa 3.5 D. Weak base, pKa 9.0 Fill in the ratio of ionized to non-ionized forms for a weak acid drug given the listed differences between pH and pKa: PH-pКа-2 pH-pKa-1 pH-pKa 2 PH-pka 1 pH-pKa lonized Non-ionized than its pKa - If your drug is...
When the term parenteral is used in regards to drug administration, this applies to drugs administered...
When the term parenteral is used in regards to drug administration, this applies to drugs administered _____ (choose all that apply). Select one or more: a. intravenously b. orally c. intramuscularly d. topically Protein synthesis occurs in all living cells. Why, then, are some antimicrobial drugs that target protein synthesis selectively toxic to bacteria? Select one: a. The protein synthesis in human cells occurs less frequently than that in bacterial cells. b. The ribosomes found in human cells and those...
Suppose of the first drug is need to compare the effects of two drugs each administered...
Suppose of the first drug is need to compare the effects of two drugs each administered to n subjects. The model for the effect 0.1 we Y=Bo+81X\i + €li, (1) while for the second drug it is Y2=Bo+B2X2; + €2i, (2) 1,...,n and X = X2 = 0. Assume that all observations are and in each case i independent and that for each i both E1 and e are normally distributed with mean 0 and variance a2 1. Obtain the...
The antibacterial drug sulfathiazole is an acid and has a pKa = 7.4. If a plasma...
The antibacterial drug sulfathiazole is an acid and has a pKa = 7.4. If a plasma sample (pH =7.4) contains 20 mg/L of sulfathiazole, what is the approximate concentration (mg/L) in saliva (pH =8.4) at the same time?
1. 9. The carboxylic acid proton of the anti-inflammatory drug Diclofenac has a pka of 4.2...
1. 9. The carboxylic acid proton of the anti-inflammatory drug Diclofenac has a pka of 4.2 One would expect this compound to be in the stomach (pH 2), and therefore in the gastric juices. Diclofenac pka = 4.2 HOO (a) protonated; soluble (b) protonated; insoluble (c) deprotonated; soluble d) deprotonated; insoluble HN _10. What would be the expected formal charge on a molecule of Diclofenac in the stomach? (a) O b) +1 (c)-1 (d) +2 (e) -2
41. Aspirin (acetylsalicylic acid) has a pKa of 3.5. (1) Calculate the ratio of ionized/unionized of the drug in the stomach where pH is 1. (i) Calculate the ratio of ionized/unionized in the intestine where pH is 6. (iii) Based on these calculations- where is aspirin absorbed within the body? (15 points) 42. What is oral daily dose for each family member? (10 points) Amount of Amount of Total Body Media Consumed Benzene Consumed Benzene Weight Water Fish Soil Water...
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of ...................... is important for the drug that is excreted unchanged. 10. pka is the ................. at which 50% of drugs present in an ionised form. 17. Renal excretion has 3 processes namely ......... .................... and ............... 18. The study of what the body does to the drug is known as ....... 19. Enzyme inducers .................. the effect of other drugs but the enzyme inhibitors ......
13. Aspirin is a common anti-inflammatory medication. A drug dose was administered orally and initial concentration of Aspirin in plasma was 33.2 mg/L. Knowing that Aspirin elimination follows zero order kinetics and drug half-life is 15 min. Determine: How long will it take for a drug concentration to decrease to 5% of its initial value? What is the elimination rate constant?
9. Describe the main differences in drug absorption if it is administered: a) Orally b) Through intracerebral injection c) Inhaled (through lungs) In which case peak concentration will be reached faster? In which case drug elimination will occur faster?
please do all parts. thank you so much
asap
Which drug would be most readily absorbed from the stomach (pH 2.0)? A. Weak acid, pKa 2.0 B. Weak acid, pKa 3.5 C. Weak base, pKa 3.5 D. Weak base, pKa 9.0 Fill in the ratio of ionized to non-ionized forms for a weak acid drug given the listed differences between pH and pKa: PH-pКа-2 pH-pKa-1 pH-pKa 2 PH-pka 1 pH-pKa lonized Non-ionized than its pKa - If your drug is...
Suppose of the first drug is need to compare the effects of two drugs each administered to n subjects. The model for the effect 0.1 we Y=Bo+81X\i + €li, (1) while for the second drug it is Y2=Bo+B2X2; + €2i, (2) 1,...,n and X = X2 = 0. Assume that all observations are and in each case i independent and that for each i both E1 and e are normally distributed with mean 0 and variance a2 1. Obtain the...
1. 9. The carboxylic acid proton of the anti-inflammatory drug Diclofenac has a pka of 4.2 One would expect this compound to be in the stomach (pH 2), and therefore in the gastric juices. Diclofenac pka = 4.2 HOO (a) protonated; soluble (b) protonated; insoluble (c) deprotonated; soluble d) deprotonated; insoluble HN _10. What would be the expected formal charge on a molecule of Diclofenac in the stomach? (a) O b) +1 (c)-1 (d) +2 (e) -2
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