Question

Hi

I'm having problems with this exercice. I'd like to know the reasoning behind the presence of absence of each please. Thank you.

Early diagnosis and proper monitoring and treatments can help children with Hyper IgM avoid some life threatening infections. However, without a successful bone marrow transplant the life expectancy of those with Hyper IgM is only ~30 years of age. At 14 years of age Daniel was able to receive a bone marrow transplant from his sister. The transplant was successful and Daniel is now in graduate school studying primary immunodeficiencies (primary immunodeficiencies are caused by inherited genetic mutations/variants). Daniel is currently working with different strains of mice, each with a homozygous deletion of a key immune system associated gene. He needs to confirm the presence or absence of different cell stages in each of the mice. You are told the deleted gene in each strain of mouse. Choose whether you expect to see each of the listed B-cell and T-cell stages, and antibodies. Deleted Gene Antibodies *(of any type) IgG antibodies Pro B-cells | Immature B- Mature B- DP Thymocytes | SP Thymocytes | Mature T- *(any pro- cells cells cells B; early or late) Artemis VprB Iga and Igß (both are knocked out/deleted) TdT

Answer 1

     Hyper-IgM syndrome is an immunoglobulin (Ig) deficiency characterized by normal or elevated serum IgM levels and decreased levels or absence of other serum immunoglobulins, resulting in susceptibility to bacterial infections.

Common variable immunodeficiency Plasma cells Agammaglobulinemia Differentiation BLYMPHOCYTE LINEAGE Pre-B cell Mature B cell Isotype Switching Somatic Hypermutation TTT Selective Ig isotype Hyper IgM deficiencies Memory cell Bone marrow Defects in T cell & B cell development TB SCID Stem cell CD4+ X-linked hyper IgM * * Effector helper functions Y PROLIFERATION TLYMPHOCYTE LINEAGE Thymus Mature T cell Effector cytotoxic, functions DiGeorge syndrome /MHC deficiency Defects in T cell development T B+ SCID Defects in T cell activation and function