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B. Procaine has an LDso of 45 mg/kg when given by IV injection, but 500 mg/kg when given orally. Provide a reason for this di
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Answer: The drugs given through IV get direct circulated into the blood circulation and it is the fastest route of administration. As drugs get circulated directly into the bloodstream, it shows it affects within 20-40 seconds and hence it is needed in a low amount.

The drugs taken orally mostly gets absorbed in the GI tract after passing to the liver where some amount of the drugs gets inactivated this is the reason that oral drugs have reduced bioavailability as compared to the IV. This is why there is a difference in the drug dose while giving orally and through IV.

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