Question

One of your authors was once involved in a research study where a newly developed pain drug was being tested. All participants completed a series of tasks intended to represent various types of somatic pain (eg., a sharp, fast pain, a dull ache, etc.), and were asked to report how much pain they experienced during each task. The pain series was completed both during an initial visit to the lab, and during a second visit about a week later. Prior to completing the tasks during the second visit, participants received either the new pain drug or a placebo What primary ethical guidelines apply to this experiment? Would any other guidelines apply if the study participants were made up of a group of patients actively receiving treatment for a pain disorder?

Answer 1

Primary Ethical guidelines for participants in the clinical trail increased the risk for new exposure to unexpected effects of a new treatment..These risks are not providing clinical benefits..When using placebo both participants and investigators may play an large role on placebo therapy..Control group receive a placebo..When using placebo first problem of deception and placebo-controlled trials (PCT) have more serious issues,when patients receiving active treatment there is harm for their trial..Even though there is high level of pain, active treatment will be at risk of death.The use of placebo downright is unethical..because when patient are like a third party they are in scientific achievement of the trial completion..
  Traditional placebo-controlled design for both placebo response to the active treatment,this help avoiding some patients traditionally..Add on design receive standard treatment..Non-conventional options will not suitable for all situations..Active -controlled trail(ACT) there is clear ethical and scientific rationale to the use of active controls in place of placebo controls,it is controversial.. ethical regulations and research guidelines placebo control delicate between the stringency of the scientific rationale for using this,use of placebo acceptable under the specific condition that where proven treatment and efficacy or safety of an intervention needed with scientific sound methodological reasons who receive placebo or no treatment..It will provide any risk or serious harm for the participants..