Medications for Psychotic Disorders: Adverse Effects of Thioridazine Therapy (RN QSEN - Patient-centered Care, Active Learning Template - Medication, RM MH RN 10.0 Chp 24)
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Homework Answers
THIORIDAZINE
EXPECTED PHARMACOLOGICAL ACTION
Thioridazine hydrochloride is a typical antipsychotic medication used for the treatment of schizophrenia.It belongs to 2- methylmercapto-10 -phenothaizines.
THERAPEUTIC ACTIONS
It is used for the treatment of mental disordes like schizophrenia,prevent suicidal tendencies,help to decrease the negative thoughts and hallucinations.
COMPLICATIONS
- drowsiness
- restlessness
- headache
- blurred vision
- lethargy
- nausea,vomiting,diarrhea
- amenorrhea
- breast engorgement
- ventricular tachycardia
- contact dermatitis
- difficulty in urinating
MEDICATION ADMINISTRATION
Available in 10 mg,25 mg,50 mg,100 mg tablets
children-0.5 to 3 mg/kg/day. 8 hourly per oral
Adult-Starting dose 50-100 mg per oral three times a day,maintenance dose is 200-800 mg/day in 2-4 divided doses
CONTRAINDICATIONS/PRECAUTIONS
Medication should be protect from light,and stored at 15-30 degree celcious. Drug should keep in tight light resistant containers using child resistant closure.
- Do not use in hypersensitivity to phenothiazines
- Avoid using with any drugs that prolong QT interval
- Avoid in lactation
- Avoid using in children with suspected Reye's syndrome
- Avoid using this drug for patients with cardiac arrythmias,hypertensive patients
- Administer phenothiazines cautiously and to increase the dose gradually in patients who are driving
- caution for orthostatic hypotension
- Monitor for leukopenia,aranulocytosis,convulsion
INTERACTIONS
- Administration of propranolol with phenothiazines increases plasma levels and its metabolites
- The drugs that may interact with this medication include-levodopa,benztropine,atropine,guanethidine,lithium,pergolide,fluoxentine,fluoxamine.
NURSING INTERVENTIONS
- Assess the heart rate,heart sounds,and report if any symptoms like palpitation,restlessness,chest discomfort,breathing difficulty,fatigue and fainting
- Watch for hyperthermia,diaphoresis,muscle rigidity,mental confusion,tachycardia,changes in blood pressure-the symptoms of neuroleptic malignant syndrome and report it immediately to physician
- Monitor for fever,sore throat,leukopenia and other signs of infection
- Assess the BP periodically
- Monitor foe signs of allergic reactions
- implement fall prevention strategies in patients with extra pyramidal symptoms and blurred vision
CLIENT EDUCATION
- Explain about the drug action ,side effects,interactions,precautions while using this drug
- Take the drug with or without food as prescribed by the physician
- Do not adjust the dose with out doctors order
- Use the medication regularly to get the desired benefit
- If any side effects occurs report it immediately
- Before taking this medication,tell to the doctor about the medical problems and the medications you are using'
- Limit the use of alcohol and beverages
- Consult your doctor before breast feeding as the drug passes in to the breast milk
- If you miss a dose ,take it as soon as you remember
- Store at room temperature away from light and moisture.
EVALUATION OF MEDICATION EFFECTIVENESS
Medication effectiveness can be evaluated by decrease in positive symptoms of schizophrenia
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