Question

B. A 12-year-old who weighs 200 pounds has been on a diet and exercise program for the past 6 months. His or her weight has not changed. Other vital signs include biood pressure 130/70 mm Ha, pulse 80, and resoiratory rate (RR) 20 at rest. Famiy history does not include severe issues with cholesterol at young ages. A patenal uncle had a myocardial intarction last year at age 42. Both granofathers died from strokes prior to age 65. The lipid profile shows low-density lipoprotein 200 and high- density lipoprotein 40. The mother wants "plls to contral the lipid levels 1. Are statins given to children? 2. Would the gender of the patient make a difference? If so in what way? 3. How would you classity this patient in terms of cardiac risk?

Answer 1

Ans)1) Most statin drugs are FDA-approved for children and teens under age 18, but only if they have a genetic condition that cause extremely high levels of LDL (bad) cholesterol.

2) Statins are equally effective at decreasing risk of coronary events in men and women, and yet women are less likely to be prescribed these cholesterol-lowering drugs than men.

To date, no compelling data support that statins are more harmful for women than for men.

- Moreover, women > 65 years have a risk 5-fold greater risk of statin myopathy compared with men younger than 65 years.

3) Statin Dosing and ACC/AHA Classification of Intensity in terms of cardiac risk:

Statin	Dosage
	Low-intensity (LDL-C reduction <30%)	Moderate-intensity (LDL-C reduction 30% to <50%)	High-intensity (LDL-C reduction >50%)
Atorvastatin	NA	10 to 20 mg	40 to 80 mg
Fluvastatin	20 to 40 mg	40 mg 2×/day; XL 80 mg	NA
Lovastatin	20 mg	40 mg	NA
Pitavastatin	1 mg	2 to 4 mg	NA
Pravastatin	10 to 20 mg	40 to 80 mg	NA
Rosuvastatin	NA	5 to 10 mg	20 to 40 mg
Simvastatin	10 mg	20 to 40 mg	NA