Question

Can someone help me with

1. pathophysiology in like a sentence or two of acetaminophen overdose.

2. risk factors of acetaminophen accidental overdose in children.

3. nursing care for accidental acetaminophen overdose

4. complications of acetaminophen overdose

5. therapeutic procedures of acetaminophen accidental overdose in children

Answer 1

1.Pathophysiology

Normally after ingestion the medication ,it forms into metabolite with the conjunction of sulphate and glucoronide and other part oxidises in cytochrome P450.But in overdosage the conjugation of sulphate and glucuronide is highly saturated in the liver decrease the glucothionine level and increasing the NAPQI in the liver causing necrosis ,liver toxicity ,otgr symptoms and death

Or

After ingestion the drug should reach peak concentration at about 4 hours ,if a dose is repeated in less than four hours ,metabolism failed leading to acetaminophen toxicity.

2.Risk factors:

• Lack of knowledge in regards to dosage by the parents
• Repeating the drug in less than 4 hours and frequently
• Rectal administration of the drug because it takes a longer time to achieve peak time
• Self administration
• Deficiency of glutathione
• Malnutrition
• Use of otger OTC medication

3.Nursing care

• Monitor the patients vitals sign a
• Assess for severe side effect and complications
• Provide a good nutritious diet which are liver friendly
• Monitor the patiwnts blood parameters as per order

4.Complications

• Hepatotoxicity/Hepatic failure
• Metabolic acidosis
• Coma

5.Therapeutic procedure

The patient are done a gastric lavage with activated charcoal

The immediate antidote to be given is N acetylcystine