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1. Your patient is a 46-year-old with a past medical history of heparin-induced thrombocytopenia with thrombosis....

1. Your patient is a 46-year-old with a past medical history of heparin-induced thrombocytopenia with thrombosis. This has been confirmed with serotonin reactive assay. Your patient is to be bridged to warfarin in the inpatient setting. What would be the optimal medication to bridge the patient given his past medical history?

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Warfarin is used in heparin induced thrombocytopenia, with thrombosis, when they are therapeutic or on non heparin anticoagulant and platelet count is 1,50000 and above. Since the patient has a past history of Heparin Induced thrombocytopenia with acute thrombosis it would be better to give fondaparinux. When transitioning to warfarin there should be minimum of 5 day bridge with non heparin anticoagulant and avoid large doses.

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