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Besides Allergic Bronchopulmonary Aspergillosis (ABPA), what other syndromes are associated with Aspergillus infections? 5. W
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4.Some ofvtge syndromes caused by Aspergillus are

  • Allergic Aspergillus sinusitis
  • Chronic pulmonary aspergillosis
  • Aspergilloma (fungus fills in the cavities of the lungs)
  • Invasive aspergillosis (the infection reaches other organ through bloodstream )

5.The mechanism of action of triazole is it stops the Cytochrome P450 which is the key source of lanosterol to register ok.As a result of blocking of Cytochrome P 450 sterols necessary for the membrane formation cannot occur and preventing fungal growth .This process is called as cessation of ergosterol synthesis which aides in fungus growth and multiplication

3.Side effects

Voricanazole

  • GI :nausea,vomiting,diarrhoea ,abdominal pain,anorexia
  • CNS:headache, slurred speech
  • CVS:palpitations ,chest pain, bruising
  • Sensory:blurred vision
  • Urinary tract:decreased urine output
  • Muscular :spasm
  • Others :fever,weakness
  • Skin:rash

Itraconazole:

  • GIT:nausea,vomiting, constipation
  • Musculoskeletal :joint pain
  • CNS :headache dizziness
  • SKIN:rash
  • REPRODUCTIVE:impotence in male ,menstruation problem in female
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