Question

Pharmacokinetics Discuss absorption - what is important to know about absorption? Discuss the different effects related to route - IM- intramuscular vs. SQ (subcutaneous) vs. PO (by mouth) Why is it important to understand the factors that alter or impair absorption of prescribed medications? What factors affect distribution once the medication enters the body? Discuss metabolism on the excretion of medication Discuss routes of excretion for medication

Answer 1

1. Absorption

Absorption is nothing but the amount of medicament concentration present in the blood to the amount of medicament ingested. It is the the first process of drug in pharmacokinetics. Most importantly absorption is take place at the plasma membrane. Absorption is of two type active and passive. Lipophilic drug is highly absorbable and water loving drug is somewhat less.

2. Three routes you want to discuss that is IM, SC and oral.

The fastest route here for drug absorption here is IM because drug is directly getting ingested into muscular then next to SC because it is given under skin and last one is oral because there is several factors which are affecting oral routes like ionization and deionization.

3. It is most important to identify factors because absorption is the first process for pharmacokinetics and responsible for amount of drug present in the blood means finally it's affect .Some factors alter the absorption while some are not e.g. solubility of drug.

4. Distribution is nothing but the movement or transfer of deih to the varil is parts of body like cells, tissues etc. Most important factors that effect distribution is the protein binding. Nice the drug get bind to blood protein dificult to excrete from body.