Question

For the Irreversible injury Necrosis list:

Risk-factors/Cause

Feature at the cellular level

Changes at Tissue Level

ATP Production Effect

Consequences

Answer 1

Irreversible Injury Necrosis :

The irreversible injury to the cells as a conclusion of meeting with noxious stimulant,always guide to the cell death.That noxious stimuli involve the contagious agents like the virus and parasites etc..,oxygen impoverishment and also the utmost environmental situations like the radiation and also the heat.The following death is called the necrosis,a word that is normally prominent from other important effect of the irreversible injury,called the cell demise by the apoptosis.

The Irreversible Injury Necrosis can takes place by the external or internal elements.

The external elements include trauma,destruction to the blood vessels and may also the inadequate blood supply to an organ or part of the body.

The Internal elements involve trophoneurotic diseases,wound and immobility of nerve cells and pancreatic enzymes are the great reason of fat necrosis.

The Cellular Changes are:

The nucleus alters in the necrosis and the features of this alterations are decided by way in which their DNA breaks down.

In the Karyolysis,the chromatin in the nucleus glow dim because of the dropping of DNA by humiliation.

In the Karyorrhexis,the diminished nucleus particles to the full dispersal.

In the Pyknosis,the nucleus get smaller and the chromatin will get compressed.

After the cell death by the necrosis,they show 2 important type of microscopic and macroscopic looks.Primarily the Liquefactive necrosis, also called the colliquative necrosis,is distinguished by incomplete or complete cessation of dead tissues and alteration into a liquid which is viscous.The dropping of tissues and the cellular shape happens in some hours in the case of Liquefactive necrosis.And the other one,the Coagulative necrosis is mainly distinguished by the continuance of usual structure of necrotic tissue for many days subsequent to cell death.

Mainly the ATP will come down to a range of 5-10 percentage of their actual range and the ATP dropping will leads to a life-threatening situation.The reason for this is,many of the cellular systems are influenced.One of the important influence is the cell swelling and the cell death.

The Major consequences are the lung infections,Brain ulcer,skin disease,stroke and Acute myocardial infarction etc...

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