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Non selective monoamine oxidase inhibitors (Mechanism of action, uses, adverse effects, preparation in market) Please explain...

Non selective monoamine oxidase inhibitors


(Mechanism of action, uses, adverse effects, preparation in market)


Please explain each one in detail thanks.

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Ans) Non selective monoamine oxidase inhibitors:

Mechanism of action:

- Inhibits the enzyme monoamine oxidase (MAO) which metabolises catecholamines and serotonin.

Uses:

- Powerful anti-depressants, as well as effective therapeutic agents for panic disorder and social phobia.

Adverse effects:

- Dry mouth.
- Nausea, diarrhea or constipation.
- Headache.
- Drowsiness.
- Insomnia.
- Dizziness or lightheadedness.
- Skin reaction at the patch site.

Preparation in market:

Nonselective MAO-A/MAO-B inhibitors.

- Hydrazine (antidepressant) Isocarboxazid (Marplan) Selective MAO-A inhibitors. Bifemelane (Alnert, Celeport) (available in Japan) Moclobemide (Aurorix, Manerix) Selective MAO-B inhibitors. Rasagiline (Azilect) Selegiline (Deprenyl, Eldepryl, Emsam).

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