Question

The Bohr effect describes the impact two effectors have on hemogloblin’s affinity for oxygen. What are these two effectors? and what effect do these effectors have on the Kd? Do they stabilize the Tense (deoxygenated) form of hemoglobin or the relaxed (oxygenate) form of hemoglobin? Where are these effectors found? In the lungs? Or in other tissues? Describe the physiologic impact of these effectors?

Answer 1

O since both coa and Ht readily react with various unit of haemoglobin molecule, a rise in Pearl or fall in pH decreases the or affinity of heamogobin. This is known as Bour's effect. Therefore two effectors are - Prog (partial pressure of cog) and pH ise, conc. of Ht l'ons. I o2-binding curve of haemoglobin is given by :- PH, PH₂ TPHCPHIT - rot on Saturation Hb of 20 40 50 CO 80 100 Ko value also called Pgo walue. e, amount of o required for saturation of son of Hb Higher the kovalne rower will be the affinity An increase of Peeg or fall in ph shift the 02 binding curve to words right side which decreases kd value ise, Pro value.. from the curve you can see that with the decreas of pH valueCred curve in fig.) PO2 increases. se ka value increases. 2 with increase of Peor or decreases in pr. decreases the o2 binding a finity ise, stabilised deoxygena red state of Hb Again decreases in pcoe or increases in PH increases the on binding affinity ise, they stabilised oxygenated state 2 In lungs Peon is significantly lower and pH is significantly higher. Therefore of readily binds with oxygen to form oxy-Hb. But in the tissues Plug is higher and also pH decreases due to the formation of H₂62 . Therefore in tissues these effectors are influence to form dox - Нь. . so, these effectors are mainly found in tissues.

I Physiological role - In the lungs Por is significantly higher therefore 02 readily combines with Hb to form oxy-Hb. But in the tissues due to metabolic activity con is formed as waste which combines with tho to for Halog which breakdown to form HT. co2 + 2 H2O3 + H+ Ho . Therefore in the tissues per decreases and due to Bohr effect of gets detouched form Hb and supply the on to the tissue for their metabolic activity: Again in the lungs where O2 concentration is high binding of or causes release of ht from to which conbines with loze to o eliminate 62 by the reverse reaction. Therefore, Bohres effect plays a significant role in 02 - transport..