Question

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Problem 9 - Panoptes In Ancient Greek mythology, the giant Argus was attributed the nickname "Panoptes" ("all seeing") because he had 100 eyes spread all over his head and body. And our friend Argus Panoptes, herem is afflicted with ubiquitous expression of the eyeless gene Aristotle and molecular biology Nowadays, researchers induce mutations in animal models to better understand mutations in humans In fruit flies, a genetic mutation causes an absence of eye formation. For this reason, the gene affected by the loss-of-function mutation in flies has been called "eyelessi (note that when eyeless is not mutated, it gives rise to normal eyes). In the comic shown above, the wise Aristotle explains to us that Argus in fact suffers of ubiquitous expression of the gene eyeless.

Answer 1

eyeless Genes affected by the loss-of-fuction mutation has been called 'eyeless'. aches in muut normal eye no eye

9.1 - Aristotle Homework. Unanswered What do you think of Aristotle's explanation? Choose the BEST answer Aristotle is wrong: studies in flies show that mutations in the Eyeless gene prevent eye formation. Panoptes wouldn't have eyes if he had a mutation in that gene. O B Aristotle is wrong: Panoptes must have a mutation in a different gene, that we could call "extraeyes" O C Aristotle is right flies and humans are different, therefore the same mutation might translate in a different effect Aristotle is right the eyeless gene is mutated but, in contrast to loss-of-function mutations seen in flles, Panoptes! mutation is a gain-of-function mutation

9.2 -Ubiquitous Homework . Unanswered Aristotle uses the word "ubiquitous" to qualify the expression of the eyeless gene in Panoptes. What does this mean? That the gene is expressed in larger quantities than normal O B That the eyeless gene is not expressed That the eyeless gene is expressed in cells and tissues where it is normally repressed O D That the eyeless gene is expressed everywhere but in the eyes

9.3 - Eyeless gene promoter Homework. Unanswered if you were able to see the sequence of Panoptes' eyeless gene and compare it with the eyeless sequence of people who'have 2 eyes, normally located in the face, what would you expect to see? Nothing, people with normal eyes don't have the eyeless gene O B Nothing, Panoptes doesn't have a mutation in the eyeless gene, but in another gene C I would expect to see a mutation in the coding sequence of the eyeless gene in Panoptes D I would expect to see a mutation in an enhancer of Panoptes' eyeless gene promoter I would expect to see a mutation in a repressor of Panoptes' eyeless gene promoter I would expect to see a mutation in the core promoter of Panoptes' eyeless gene

9.4 - Eyes Homework – Unanswered How can you explain the fact that most people only have two eyes, located in the face, while Panoptes is covered in eyes? Choose the best explanation Only eye cells have the eyeless gene in normal people Non-eye cells produce a protein that actively repress the expression of eyeless. Eye cells receive signals from neighbor cells that inhibit the production of the gene regulator binding to this repressor oc Eye cells produce a protein that actively enhances the expression of eyeless. Non-eye cells receive signals from neighbor cells that inhibit the production of the gene regulator binding to this enhancer