Question

"ybase.01. eports/rDaru Nature of the Allele Allele class amorphic allele - genetic evidence (Georgiev and Corces, 1995, Geyer et al., 1990) loss of function allele (Drapeau et al., 2006) spontaneous (Morris et al., 1999) Mutagen Mutations Mapped to the Genome Type Location X:356,680.356,680 [+] References (Geyer et al., 1990) point mutation Additional Notes Comment: Ato C tranversion in the ATG translation initiatio n codon. The reference sequence strain, iso-1, C arries the y' mutation. Associated Sequence Data DDBJ / EMBLI GenBank DNA sequence Protein sequence UniProtKB/Swiss-Prot UniProtKB/TrEMBL Progenitor genotype Cytology Polytene chromosomes normal. (Campuzano et al, 1985) Nature of the lesion Statement Known mutation in sequenced strain: single base change in start codon (see FBrf0051634). Reference (FlyBase Curators, 2002-) Deletion of the y promoter, not enhancer. (Georgiev and Kozitsina, 1992) A to C tranversion in the ATG translation initiation codon. (Geyer et al., 1990) Carried on aberration C(1,1;YL)RA:YL C(1:Y)3 C(1,Y)7 C(1;YS)4 C(1)94-2A C(1)A C(1)DX C(1)RM-W8 CIRR1

Answer 1

In this sequencing, the loss of function is being studied as a transversion is occurring in the initiation codon and also the promoter sequence has a deletion which makes the loss of function gene. Hence the correct answer is: We are investigating whether the flies with yellow bodied phenotype harbor a loss of function allele at the yellow locus.

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