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"ybase.01. eports/rDaru Nature of the Allele Allele class amorphic allele - genetic evidence (Georgiev and Corces, 1995, Geyer et al., 1990) loss of function allele (Drapeau et al., 2006) spontaneous (Morris et al., 1999) Mutagen Mutations Mapped to the Genome Type Location X:356,680.356,680 [+] References (Geyer et al., 1990) point mutation Additional Notes Comment: Ato C tranversion in the ATG translation initiatio n codon. The reference sequence strain, iso-1, C arries the y' mutation. Associated Sequence Data DDBJ / EMBLI GenBank DNA sequence Protein sequence UniProtKB/Swiss-Prot UniProtKB/TrEMBL Progenitor genotype Cytology Polytene chromosomes normal. (Campuzano et al, 1985) Nature of the lesion Statement Known mutation in sequenced strain: single base change in start codon (see FBrf0051634). Reference (FlyBase Curators, 2002-) Deletion of the y promoter, not enhancer. (Georgiev and Kozitsina, 1992) A to C tranversion in the ATG translation initiation codon. (Geyer et al., 1990) Carried on aberration C(1,1;YL)RA:YL C(1:Y)3 C(1,Y)7 C(1;YS)4 C(1)94-2A C(1)A C(1)DX C(1)RM-W8 CIRR1

Answer 1

4.Ans.

-It is a point mutation

-it is a loss of function mutation

-It resulted in destruction of a start codon

Explanation: The mutation that occurs is point mutation which involves substitution of a single base. This mutation leads to amorph i.e. loss of function. This loss of fuction is caused due to change in the translation initiation codon i.e. start codon by underdoing single nucleotide substitution in the start codon.. There is substitution of adenine (A) by cytosine (C). This is transversion base substitution because adenine (A) is a purine base which is substituted by a pyrimidine base i.e. cytosine (C).