![Question 5: Below is the chemical equation catalyzed by isocitrate dehydrogenase (i... the third reaction in the citric acid cycle). α-ketoglutarate + CO2 + NADH + H+ isocitrate NAD (a) Calculate the physiological ΔG of the isocitrate dehydrogenase reaction at 25°C and pl 17.0 given: [NAD+]IN ADH]-8; [α-ketoglutarate] = 0.1 mM: [isocitrate] = 0.02 mM; standard state conditions for CO2 and H: and ΔG (b) Is this reaction a likely site for metabolic control? Explain. 。,--21.0 kJ/mol?](http://img.homeworklib.com/questions/fc6a0c20-bf8b-11ea-baaa-ad4dc844f515.png?x-oss-process=image/resize,w_560)
Homework Answers
For the given reaction
a) dG = dGo + RT lnK
pH = -log[H+] = 7
[H+] = 1 x 10^-7 M
K = 0.1 x 1 x 10^-7 x 1/0.02 x 8 = 6.25 x 10^-8
dG = -21 x 1000 + 8.314 x 298 ln(6.25 x 10^-8) = -62.10 kJ/mol
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Question 5: Below is the chemical equation catalyzed by isocitrate dehydrogenase (i... the third reaction in...
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