Immunology: Describe the two different domains of TLRs and their respective functions.
Immunology:
Describe the two different domains of TLRs and their respective functions.
Homework Answers
Ans):
The first domain of the TLR is an extracellular domain, also known as the pathogen-recognition domain, which contains a hydrophobic, leucine-rich repeat region (LRR) forming a horseshoe-shaped structure that binds specifically to arrays on microbial surfaces. The second domain of the TLR is the cytoplasmic signaling domain, also known as the Toll interleukin receptor (TIR) domain, which facilitates the transmission of information to the interior of the cell.
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Immunology:
Describe the two different domains of
TLRs and their respective functions.
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