Synthesis of Aspirin Lab Quesitons 1. what major change in the IR spectrum would be expected...
Synthesis of Aspirin Lab Quesitons
1. what major change in the IR spectrum would be expected upon conversion of salicylic acid to acetyl salicylic acid?
2. what purpose did the sulfuric acid serve in this reaction? what would happen if you used phosphoric acid, H3PO4 instead?
3. pick a prescription drug that you or your friends use. describe how it was synthesized
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Synthesis of Aspirin Lab Quesitons
1. what major change in the IR spectrum would be expected...
PRELAB EXERCISE EXPERIMENT 21 Synthesis of Aspirin (Acetylsalicylic Acid) 1. What is the purpose of sulfuric...
PRELAB EXERCISE EXPERIMENT 21 Synthesis of Aspirin (Acetylsalicylic Acid) What is the purpose of sulfuric acid or phosphoric acid used in the acetylation reaction? Use equations to explain this purpose. The procedure calls for cautious addition of water to the reaction mixture while it is still hot. What purpose does the addition of water serve and why should the addition be done while the reaction mixture is hot? Provide an equation for the reaction involved.Using the quantities of salicylic acid and acetic anhydride...
1) In the lab of synthesis of aspirin, how will adding HCl instead of phosphoric acid...
1) In the lab of synthesis of aspirin, how will adding HCl instead of phosphoric acid affect the outcome of the experiment. 2) In the lab of synthesis of aspirin, what is the purpose of using KMnO4 solution? 3) Suggest 2 other ways(besides use of hickman still) that you can use to influence the direction of reaction equilibrium in the lab dehydration of alcohol to alkenes 4) How will the absence of hickman still affect the outcome of the experiment...
Question 16 What is the purpose of adding phosphoric acid in aspirin synthesis A) enhance the...
Question 16 What is the purpose of adding phosphoric acid in aspirin synthesis A) enhance the nucleophilicity of the OH of salicylic acid B) enhance the electrophilicty of acetic anhydride enhance the nucleophilicity of acetic anhydride D) enhance the electrophilicty of the carbonyl of salicylic acid А 8 С Question 17 Which statement(s) is correct for electrophilic aromatic substitution (EAS)? (multiple answer) ferrocene is more reactive than benzene A. benzene is more reactive than ferrocene B C. ferrocene is more...
Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1....
Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1. The Synthesis of Aspirin Record the weight of your aspirin, and calculate the percentage yield. Base the yield on salicylic acid since we acetic anhydride was used. Show all calculations. Weight of aspirin d. 08035 Yield of aspirin 2. Contaminants in Aspirin What was the color of the salicylic acid-ferric chloride test solution? On the basis of color is either your aspirin or commercial...
The weight of aspirin is 1.6 g and the reagents used to perform this synthesis was...
The weight of aspirin is 1.6 g and the reagents used to perform
this synthesis was 1.48 g salicylic acid, 3 mL ethanoic anhydride,
3 drops H2SO4, and acetylsalicylic acid
Synthesis of Aspirin Post-lab Questions February 2, 2018 Discussion of the aspirin product including, 1. The calculated percent yield of your aspirin product and comments on its purity based on the literature melting point and literature IR spectrum. Label all major peaks in the IR spectrum of your aspirin product....
please help Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid,...
please help
Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
Pre-lab Assignment: Synthesis of Aspirin 1. What is the chemical name for aspirin? 2. How does...
Pre-lab Assignment: Synthesis of Aspirin 1. What is the chemical name for aspirin? 2. How does aspirin work in the human body? 3. What is the name of the compound that was isolated from the bark of the willow and had a similar effect as aspirin? 4, what is a common side effect of the compound from #4? 5. Draw and label the complete setup to perform vacuum filtration. 6. What is the theoretical yield for aspirin if you start...
1) Which reactant, salicylic acid or acetic anhydride, is in excess? Show your work. 2) If you we...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Pre-lab Questions: Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester...
Pre-lab Questions:
Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
Experiment 12: Synthesis of Benzoic Acid pre-lab (4 pts) 1 (2 pts) Refer to the introduction...
Experiment 12: Synthesis of Benzoic Acid pre-lab (4 pts) 1 (2 pts) Refer to the introduction on the general process of hydrolysis of nitriles to carboxylic acids. Starting with benzonitrile (shown below), show how it is converted to benzoic acid under basic conditions. N 2) (2 pts) The reaction for the synthesis of benzoic acid via benzonitrile hydrolysis is shown below: 1) NaOH, HO YOH + NaCl 2) HCI, H,0 Benzonitrile Density = 1.0 g/mL MM = 103.04 g/mol Benzoic...
PRELAB EXERCISE EXPERIMENT 21 Synthesis of Aspirin (Acetylsalicylic Acid) What is the purpose of sulfuric acid or phosphoric acid used in the acetylation reaction? Use equations to explain this purpose. The procedure calls for cautious addition of water to the reaction mixture while it is still hot. What purpose does the addition of water serve and why should the addition be done while the reaction mixture is hot? Provide an equation for the reaction involved.Using the quantities of salicylic acid and acetic anhydride...
Question 16 What is the purpose of adding phosphoric acid in aspirin synthesis A) enhance the nucleophilicity of the OH of salicylic acid B) enhance the electrophilicty of acetic anhydride enhance the nucleophilicity of acetic anhydride D) enhance the electrophilicty of the carbonyl of salicylic acid А 8 С Question 17 Which statement(s) is correct for electrophilic aromatic substitution (EAS)? (multiple answer) ferrocene is more reactive than benzene A. benzene is more reactive than ferrocene B C. ferrocene is more...
Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1. The Synthesis of Aspirin Record the weight of your aspirin, and calculate the percentage yield. Base the yield on salicylic acid since we acetic anhydride was used. Show all calculations. Weight of aspirin d. 08035 Yield of aspirin 2. Contaminants in Aspirin What was the color of the salicylic acid-ferric chloride test solution? On the basis of color is either your aspirin or commercial...
The weight of aspirin is 1.6 g and the reagents used to perform
this synthesis was 1.48 g salicylic acid, 3 mL ethanoic anhydride,
3 drops H2SO4, and acetylsalicylic acid
Synthesis of Aspirin Post-lab Questions February 2, 2018 Discussion of the aspirin product including, 1. The calculated percent yield of your aspirin product and comments on its purity based on the literature melting point and literature IR spectrum. Label all major peaks in the IR spectrum of your aspirin product....
please help
Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
Pre-lab Assignment: Synthesis of Aspirin 1. What is the chemical name for aspirin? 2. How does aspirin work in the human body? 3. What is the name of the compound that was isolated from the bark of the willow and had a similar effect as aspirin? 4, what is a common side effect of the compound from #4? 5. Draw and label the complete setup to perform vacuum filtration. 6. What is the theoretical yield for aspirin if you start...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Pre-lab Questions:
Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
Experiment 12: Synthesis of Benzoic Acid pre-lab (4 pts) 1 (2 pts) Refer to the introduction on the general process of hydrolysis of nitriles to carboxylic acids. Starting with benzonitrile (shown below), show how it is converted to benzoic acid under basic conditions. N 2) (2 pts) The reaction for the synthesis of benzoic acid via benzonitrile hydrolysis is shown below: 1) NaOH, HO YOH + NaCl 2) HCI, H,0 Benzonitrile Density = 1.0 g/mL MM = 103.04 g/mol Benzoic...
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