Cell & Molecuar Biology: Cell-Division Cycle What signals feed into the G1-to-S transition? Name one controller...
Cell & Molecuar Biology: Cell-Division Cycle
What signals feed into the G1-to-S transition? Name one controller for this transition. Describe one target of this controller and how the controller regulates that target. (Please be specific)
Homework Answers
Cell cycle progress is regulated by concentration of cyclins. The kinases when associated with cyclins, also known as CDKs help in phosphorylating various proteins involved in cell cycle.
During progression of G1 to S phase, G1 Cyclin- CDKs,i.e, D-CDK 4/6. This enzyme phosphorylates retinoblastoma. This initiates the transcription factor EGF. And the cell proceeds from G1 to S phase.
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Cell & Molecuar Biology: Cell-Division Cycle
What signals feed into the G1-to-S transition? Name one
controller...
HW#4-6 Unanswered The four standard phases of the Cell Cycle are: 1. A G1, S, G2, M B G1, G2, G3,...
HW#4-6 Unanswered The four standard phases of the Cell Cycle are: 1. A G1, S, G2, M B G1, G2, G3, G4 C G, DNA, P, Division Prophase, metaphase, anaphase, telophase
HW#4-6 Unanswered The four standard phases of the Cell Cycle are: 1. A G1, S, G2, M B G1, G2, G3, G4 C G, DNA, P, Division Prophase, metaphase, anaphase, telophase
Explain the central role played by CdK (cell cycle-dependent kinases) in the transition from G1 to...
Explain the central role played
by CdK (cell cycle-dependent kinases) in the transition from G1 to
S and preRC to preIC at DNA origins of replication. Use the diagram
below for help
RC ORC Cyclin A/B+ Cdk APC Licensed DNA Rb DNA replication MCM ORC Rb S G1 D cyclins Cdk4/6 Cyclin A Cdk2 Cyclin E+Cdk2 ORC DNA licensing inactivation Skp2 CUL4 → Cok
• In the cell, DNA is duplicated in the G1 phase S phase G2 phase Division...
• In the cell, DNA is duplicated in the G1 phase S phase G2 phase Division stage Which of the following statements is true? Chromatin is more compacted in prophase than during the G2 phase The key even of Sphase is the segregation of sister chromatids • • The mitotic spindle first appears during anaphase The cell increases in size during metaphase Which of the following correctly represents the order of the phases in the cell cycle? Mitosis, S phase,...
Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A ge...
Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A gene that inhibits the transition from G1 to S phase c. d. A gene that promotes cell growth, combined with a hyperactive promoter How would methylation of the promoter of the gene in question 3c affect the cell? Be specific using what you know about the...
A. Explain how CDK activation in G1 leads to commitment to the cell cycle (the “restriction...
A. Explain how CDK activation in G1 leads to commitment to the cell cycle (the “restriction point” aka “R” in vertebrates aka START in yeast). Be sure to include G1-cyclin/CDK, Rb and E2F in your explanation. Include as much mechanistic explanation as possible. B. List two specific sequences/structures found in the DNA/chromosome, and their functions, that act to ensure that the number and morphology of chromosomes are constant from one generation of the cell to the next. Explain.
Name: 2. You cell cycle. Describe this process, including DNA replication (when is occurs and what is produced), The major portions of the cell cycle and what those portions are divided into. For...
Name: 2. You cell cycle. Describe this process, including DNA replication (when is occurs and what is produced), The major portions of the cell cycle and what those portions are divided into. For the cell division process you should use a chromosome number of 2N-4, instead of the real human chromosome number of 2N-46 have a broken leg and you realize that in order to heal your body needs to proceed through the
Name: 2. You cell cycle. Describe this...
1. Draw the cell cycle including: 2. G1, S, G2, Mitosis, Meiosis I, Meiosis II. What...
1. Draw the cell cycle including: 2. G1, S, G2, Mitosis, Meiosis I, Meiosis II. What happens in each? - briefly 3. ASSUME your cell is diploid with 6 chromosomes, and genes A, B, C.
Cancer biology 23. The levels of these proteins fluctuate dramatically as cells progress through the cell...
Cancer biology
23. The levels of these proteins fluctuate dramatically as cells progress through the cell cycle. These fluctuations are tightly coordinated with the schedule of advances through the various cell cycle phases. For a particular subtype, extracellular signals, notably those conveyed by growth factors, strongly influence their levels. These proteins are: cdc25-like phosphatases b. Cdk kinases c. Protectins d. Cyclins 24. Which of the following best describes the biochemistry that correlates to one of the cell cycle functions of...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do cells divide? 2. What are the major events of eukaryotic cell division that enable the genome of one cell to be passed on to two daughter cells? 3. How do chromosomal numbers change throughout the human life cycle? The Mitotic Cell Cycle 4. What are the phases of the cell cycle? What is the sequence of events that occurs during each phase? 5. What...
In the cell division cycle, what are the processes that determine organ and body size? Briefly...
In the cell division cycle, what are the processes that determine organ and body size? Briefly explain each one.
HW#4-6 Unanswered The four standard phases of the Cell Cycle are: 1. A G1, S, G2, M B G1, G2, G3, G4 C G, DNA, P, Division Prophase, metaphase, anaphase, telophase
HW#4-6 Unanswered The four standard phases of the Cell Cycle are: 1. A G1, S, G2, M B G1, G2, G3, G4 C G, DNA, P, Division Prophase, metaphase, anaphase, telophase
Explain the central role played
by CdK (cell cycle-dependent kinases) in the transition from G1 to
S and preRC to preIC at DNA origins of replication. Use the diagram
below for help
RC ORC Cyclin A/B+ Cdk APC Licensed DNA Rb DNA replication MCM ORC Rb S G1 D cyclins Cdk4/6 Cyclin A Cdk2 Cyclin E+Cdk2 ORC DNA licensing inactivation Skp2 CUL4 → Cok
• In the cell, DNA is duplicated in the G1 phase S phase G2 phase Division stage Which of the following statements is true? Chromatin is more compacted in prophase than during the G2 phase The key even of Sphase is the segregation of sister chromatids • • The mitotic spindle first appears during anaphase The cell increases in size during metaphase Which of the following correctly represents the order of the phases in the cell cycle? Mitosis, S phase,...
Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A gene that inhibits the transition from G1 to S phase c. d. A gene that promotes cell growth, combined with a hyperactive promoter How would methylation of the promoter of the gene in question 3c affect the cell? Be specific using what you know about the...
Name: 2. You cell cycle. Describe this process, including DNA replication (when is occurs and what is produced), The major portions of the cell cycle and what those portions are divided into. For the cell division process you should use a chromosome number of 2N-4, instead of the real human chromosome number of 2N-46 have a broken leg and you realize that in order to heal your body needs to proceed through the
Name: 2. You cell cycle. Describe this...
1. Draw the cell cycle including: 2. G1, S, G2, Mitosis, Meiosis I, Meiosis II. What happens in each? - briefly 3. ASSUME your cell is diploid with 6 chromosomes, and genes A, B, C.
Cancer biology
23. The levels of these proteins fluctuate dramatically as cells progress through the cell cycle. These fluctuations are tightly coordinated with the schedule of advances through the various cell cycle phases. For a particular subtype, extracellular signals, notably those conveyed by growth factors, strongly influence their levels. These proteins are: cdc25-like phosphatases b. Cdk kinases c. Protectins d. Cyclins 24. Which of the following best describes the biochemistry that correlates to one of the cell cycle functions of...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do cells divide? 2. What are the major events of eukaryotic cell division that enable the genome of one cell to be passed on to two daughter cells? 3. How do chromosomal numbers change throughout the human life cycle? The Mitotic Cell Cycle 4. What are the phases of the cell cycle? What is the sequence of events that occurs during each phase? 5. What...
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