A. Explain how CDK activation in G1 leads to commitment to the cell cycle (the “restriction...
A. Explain how CDK activation in G1 leads to commitment to the cell cycle (the “restriction point” aka “R” in vertebrates aka START in yeast). Be sure to include G1-cyclin/CDK, Rb and E2F in your explanation. Include as much mechanistic explanation as possible.
B. List two specific sequences/structures found in the DNA/chromosome, and their functions, that act to ensure that the number and morphology of chromosomes are constant from one generation of the cell to the next. Explain.
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A. Explain how CDK activation in G1 leads to commitment
to the cell cycle (the “restriction...
Explain the central role played by CdK (cell cycle-dependent kinases) in the transition from G1 to...
Explain the central role played
by CdK (cell cycle-dependent kinases) in the transition from G1 to
S and preRC to preIC at DNA origins of replication. Use the diagram
below for help
RC ORC Cyclin A/B+ Cdk APC Licensed DNA Rb DNA replication MCM ORC Rb S G1 D cyclins Cdk4/6 Cyclin A Cdk2 Cyclin E+Cdk2 ORC DNA licensing inactivation Skp2 CUL4 → Cok
Explain the discovery, mechanism of action and function of AID (activation-induced deaminase)? SOMATIC HYPERMUTATION (Figures 7...
Explain the discovery, mechanism of action and function of AID
(activation-induced deaminase)?
SOMATIC HYPERMUTATION (Figures 7 and 8). Indeed, the discovery of AID provided the missing MSH2-deficient mice had previously been taken to indicate that somatic mutation is initiated by diversification at C:G pairs with MSH2-mediated recognition then triggering a subsequent stage of diversification at A:T pairs. Such a two-stage model was supportedations by the observation that CG-biased mutation was also a characteristic of somatic mutation in B-c nes9 and...
Explain the central role played
by CdK (cell cycle-dependent kinases) in the transition from G1 to
S and preRC to preIC at DNA origins of replication. Use the diagram
below for help
RC ORC Cyclin A/B+ Cdk APC Licensed DNA Rb DNA replication MCM ORC Rb S G1 D cyclins Cdk4/6 Cyclin A Cdk2 Cyclin E+Cdk2 ORC DNA licensing inactivation Skp2 CUL4 → Cok
Explain the discovery, mechanism of action and function of AID
(activation-induced deaminase)?
SOMATIC HYPERMUTATION (Figures 7 and 8). Indeed, the discovery of AID provided the missing MSH2-deficient mice had previously been taken to indicate that somatic mutation is initiated by diversification at C:G pairs with MSH2-mediated recognition then triggering a subsequent stage of diversification at A:T pairs. Such a two-stage model was supportedations by the observation that CG-biased mutation was also a characteristic of somatic mutation in B-c nes9 and...
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