Once proteins have been sorted by the Golgi apparatus they are released from the Golgi apparatus...
Once proteins have been sorted by the Golgi apparatus they are released from the Golgi apparatus in vesicles to be transported to its target membrane. How is a vesicle able to identify its target membrane and what happens to the vesicle once it finds its target membrane?
Homework Answers
Fusion between the vesicular membrane and the target membrane is mediated by binding between specific pairs of v-SNAREs and t-SNAREs on the vesicle and target membranes respectively. Rab GTP-binding proteins are required to facilitate formation of v-SNARE/t-SNARE complexes. Following membrane fusion, the NSF/SNAP proteins disassemble the SNARE complex.
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Once proteins have been sorted by the Golgi apparatus they are
released from the Golgi apparatus...
7a. What would be the resulting effect of vesicle transport from Golgi to membrane being slower...
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hich of the following organelles are the destination for proteins synthetized by cytosolic ribosomes Peroxisomes, endoplasmic...
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When the fungal metabolite brefeldin A is added to cells, the Golgi apparatus largely disappears and...
When the fungal metabolite brefeldin A is added to cells, the
Golgi apparatus largely disappears and the Golgi proteins intermix
with those in the ER. Brefeldin A treatment also causes the rapid
dissociation of some Golgi-associated peripheral membrane proteins,
including subunits of the COPI coat. This implies that brefeldin A
prevents transport involving COPI-coated vesicles by blocking the
assembly of coats and thus the budding of transport vesicles. In
principle, brefeldin A could block formation of COPI-coated
vesicles at any...
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hich of the following organelles are the destination for proteins synthetized by cytosolic ribosomes Peroxisomes, endoplasmic reticulum, and the Golgi apparatus The Golgi apparatus, lysosomes, and the nucleus Peroxisomes, mitochondria, and lysosomes Peroxisomes, mitochondria, and the nucleus Mitochondria, lysosomes, and the nucleus What is the fate of N-terminus signal peptide after it directs the protein to the ER translocator O It is linked to the transported protein by S-S bond It is cleaved and then released into the membrane It...
When the fungal metabolite brefeldin A is added to cells, the
Golgi apparatus largely disappears and the Golgi proteins intermix
with those in the ER. Brefeldin A treatment also causes the rapid
dissociation of some Golgi-associated peripheral membrane proteins,
including subunits of the COPI coat. This implies that brefeldin A
prevents transport involving COPI-coated vesicles by blocking the
assembly of coats and thus the budding of transport vesicles. In
principle, brefeldin A could block formation of COPI-coated
vesicles at any...
(NOTE: This question will require information from Unit 6 in order to answer it). Problem 4.2.3 (tags: #SNARES, #vesicle transport) Consider the v-SNAREs that directly transport vesicles from the trans Golgi network (TGN) to the plasma membrane. They, like all other v-SNAREs, are membrane proteins that are integrated into the membrane of the ER during their biosynthesis, and are then transported by vesicles to their destination. Thus, transport vesicles budding from the ER contain at least two kinds of V-SNARES...
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