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For clathrin coated vesicle trafficking: If another molecule was bound to the GTP pocket which could...

For clathrin coated vesicle trafficking:

If another molecule was bound to the GTP pocket which could not hydrolyze GDP, what is the affect on the vesicles?
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G protein are molecular switches: they are active when GTP is bound to them and in active when GTP is bound to them and inactive when GDP is bound. In addition they have intrinsic,although weak. GTpase activity as such,they eventually turn themselves off when they hydrolyze the bound GTP to GDP. In active state they can stimulate enzymes and ions channels, and affect the cytoskeleton and vesicular trafficking. There are se veral G protein families,but only two that have been G protein and large G protein.

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