Homework Answers
Ans- Superoxide has the ability to leach excess iron from enzymic clusters like iron- sulfur clusters.This leads to an elevation in free iron that increases the rate of DNA damage.
DNA damage is mainly caused by the presence of free radicals. Superoxide serves as a reductant for the pool of free iron released from those clusters .This elevated level of free iron generates the hydroxyl radical( free radical) by transferring the electrons to hydrogen peroxide.The hydroxyl radical then attacks the DNA and damages it.The chemical reaction is-
Fe2+ + H2O2 ----> Fe3+ + OH- + OH. ( Here OH. is the hydroxyl radical , a type of free radical with an unpair electron which causes DNA damage.)
Hence the main reason would be that the elevated level of free iron released from iron- sulfur clusters damage the DNA by generating hydroxyl radical( OH.).This free radical causes damage to DNA.
Add Answer to:
Why does superoxide damage DNA more than any other macromolecule? (1 pt)
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make...
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
*Why are alpha particles more effective than betas for causing tissue damage, but x-rays and gamma...
*Why are alpha particles more effective than betas for causing tissue damage, but x-rays and gamma rays are equally effective (that is for each joule of energy deposited by radiation in a kg of tissue, why alpha particles do more damage than betas, but gamma rays do an equal amount of damage.) This was from class only.
Question 1 1 pts Primase is accurate than DNA polymerase at copying a DNA template. more...
Question 1 1 pts Primase is accurate than DNA polymerase at copying a DNA template. more less Question 2 1 pts J is a common type of DNA damage that, if not repaired, can lead to the loss of a nucleotide and possibly a shift in the reading frame. Depurination Deamination Question 3 1 pts Each time the genome is replicated, half the newly synthesized DNA is stitched together from Okazaki fragments. True False Question 4 1 pts The complement...
are there any archaean groups that share ancestors more closely with Eukarya than with other archaeans?...
are there any archaean groups that share ancestors more closely with Eukarya than with other archaeans? Name one Does this mean Archaea is a mono, ploy or para phyletic group? Why?
Why is DNA replication in living cells so much more complicated than DNA amplification in the...
Why is DNA replication in living cells so much more complicated than DNA amplification in the lab? Could organisms evolve a system as simple as PCR?
1 pt 1 Question 1 Why must one strand of DNA be replicated in fragments? DNA...
1 pt 1 Question 1 Why must one strand of DNA be replicated in fragments? DNA polymerase can only add 20 nucleotides in a strand and then must start over ODNA polymerase can only add nucleotides to the 3 hydroxyl of a growing strand O it would be too crowded for two DNA polymerases to be going in the same direction all of the above Question 2 1 pt the DNA would spin and possibly break while being opened in...
“Although the United States spends more on healthcare than does any other country, a scarcity of...
“Although the United States spends more on healthcare than does any other country, a scarcity of funds to provide for all our medical needs and population groups—such as the uninsured and those on Medicaid—still exists. Therefore choices must be made.” Short answer:How are the choices among the approaches to allocate funds for medical care better understood?
Interpret this data. Why do you think bone marrow cells would be affected more than other...
Interpret this data. Why do you think bone marrow cells would be
affected more than other cell types?
4. The data below helps us to understand both how AZT affects the enzyme that you named above and how it may affect other cells. Interpret this data in light of your answers to the previous questions. Why do you think bone marrow cells would be affected more than other cell types. Fraction of Enzyme bound to Inhibitor Human DNA dependent RNA...
More roses are supplied on Valentine’s Day than on any other day of the year. If...
More roses are supplied on Valentine’s Day than on any other day of the year. If florists increase their supply of roses on Valentine’s day, why might higher prices convince florists to increase the number of roses they offer for sale? Give a specific example of a hypothetical cost increase faced by florists as they offer more roses for sale.
QUESTION 20 Why does meiosis result in more genetic variation than can be explained by mutation...
QUESTION 20 Why does meiosis result in more genetic variation than can be explained by mutation alone? Select all that apply. Oa. because of the events of meiosisI b because of the events of meiosis I because of crossing over d.not all the DNA gets replicated
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
Question 1 1 pts Primase is accurate than DNA polymerase at copying a DNA template. more less Question 2 1 pts J is a common type of DNA damage that, if not repaired, can lead to the loss of a nucleotide and possibly a shift in the reading frame. Depurination Deamination Question 3 1 pts Each time the genome is replicated, half the newly synthesized DNA is stitched together from Okazaki fragments. True False Question 4 1 pts The complement...
1 pt 1 Question 1 Why must one strand of DNA be replicated in fragments? DNA polymerase can only add 20 nucleotides in a strand and then must start over ODNA polymerase can only add nucleotides to the 3 hydroxyl of a growing strand O it would be too crowded for two DNA polymerases to be going in the same direction all of the above Question 2 1 pt the DNA would spin and possibly break while being opened in...
Interpret this data. Why do you think bone marrow cells would be
affected more than other cell types?
4. The data below helps us to understand both how AZT affects the enzyme that you named above and how it may affect other cells. Interpret this data in light of your answers to the previous questions. Why do you think bone marrow cells would be affected more than other cell types. Fraction of Enzyme bound to Inhibitor Human DNA dependent RNA...
QUESTION 20 Why does meiosis result in more genetic variation than can be explained by mutation alone? Select all that apply. Oa. because of the events of meiosisI b because of the events of meiosis I because of crossing over d.not all the DNA gets replicated
Most questions answered within 3 hours.
-
Oxidative phosphorylation is achieved through chemiosmotic
coupling, which turns chemical energy into osmotic potential energy
that...
asked 46 minutes ago -
Hollywood Shoes would like to maintain their cash account at a
minimum level of $64,000, but...
asked 45 minutes ago -
Proteins CtrA-P, DnaA, and GcrA behave similarly to what
molecule in the Eukaryotic Cell Cycle?
asked 49 minutes ago -
TRUE OR FALSE
In case of a competitive tender procedure, in the request for
quotation, the...
asked 57 minutes ago -
I am a little behind please provide some explanation, will
provide thumbs up.
This question considers...
asked 59 minutes ago -
Let say the utility function as U(X,Y) = lnX + Y. Show that the
marginal rate...
asked 1 hour ago -
A current of I=8.0A is flowing in a typical extension cord of
length L=3.00m. The cord...
asked 1 hour ago -
1. When balancing the equation H2SO4 (aq) + NaOH (aq) →
Na2SO4(aq) + H2O(aq), would you...
asked 1 hour ago -
Provide a definition of “classification hierarchy” and
illustrate your definition with an example of how and...
asked 1 hour ago -
1. Describe the four main green solvents. Provide one example of
the use of each solvent....
asked 1 hour ago -
International ethics focus on:
1) exploitation of labor
2)corruption
3) environmental impact
4) none of the...
asked 1 hour ago -
Costing Models You work for XYZ trucking and your boss has asked
you to figure out...
asked 1 hour ago