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The next two questions refer to the following statement: In mitosis Ran-GTP is found at a...

The next two questions refer to the following statement: In mitosis Ran-GTP is found at a higher concentration in the vicinity of the chromosomes than in regions of the cell far from the chromosomes.

Why is the concentration of Ran-GTP higher in the vicinity of the chromosomes than in regions of the cell far from the chromosomes?

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Ran-GTP is higher in the vicinity of the chromosomes than in regions of the cell far from the chromosomes due to the following reason.RanGDP is converted into RanGTP through the action of RCC1, the nucleotide exchange factor for Ran. RCC1 is also known as RanGEF (Ran Guanine nucleotide Exchange Factor). The association of RanGEF with sperm chromatin will produce a Ran-GTP “atmosphere” very near to the chromatin surface, which later induces vesicle fusion and nuclear envelope formation.

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