Question

Excess dietary fat can be converted into cholesterol in the liver. When palmitate labeled with^14C at every odd-numbered carbon is added to liver homogenate, where does the radiolabel appear in mevalonate?
which structure is correct and why?

are the radiolabelled carbons at C 1 3 5 or at C 2 3 5?

The following structure indicates position of labeled "C at carbon atom. Palmitate will be broken down into acetyl CoA, which will then be incorporated into mevalonate. CoASH Mevalonate As it is showed in the mevalonate structure the labeled Carbons appear in C1, C3 and C5 (blue carbons)

Answer 1

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