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Krebs cycle fill in the blank...

In reaction 1 of the Krebs cycle, acetyl-CoA forme

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  1. Acetyl –CoA formed in the pyruvate dehydrogenase reaction condenses with the four-carbon compound oxaloacetae to form citrate with the elimination of coenzyme A. Since the product has three carboxyl groups, this pathway is referred to as the tricarboxylic acid cycle.
  2. This product then undergoes isomerization to form isocitrate. The enzyme called aconitase because the compound cis-aconitase is an intermediate of the reaction.
  3. Eliminates CO2 to form the 5-carbon dicarboxylic acid alpha-ketoglutarate. Oxidation also occurs, with electrons transferred from the substrate to NAD+.
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