Question

Discuss the metabolic importance and implications of malonyl CoA functioning as a negative allosteric regulator of carnitine palmitoyl transferase-1 (CPT-1; also known as as carnitine acyltransferase-1 or CAT-1)?

(Explain and answer thoroughly)

Answer 1

It plays a major role in chain elongation in fatty acid biosynthesis.
Malonyl CoA function as a inhibitor of fatty acids from associating with carnitine by regulating carnitine acyltransferase activity thus preventing them from entering the mitochondria, where fatty acid oxidation.
The most common function of malonyl-CoA is the regulation systems of carnitine acyltransferases by allosteric inhibition by malonyl-CoA which is one of the intermediate in the synthesis of fatty acids. Malonyl-CoA inhibits long-chain carnitine acyltransferase activity by all three enzymes at similar concentrations in the physiological range.