Question

Myasthenia gravis is an autoimmune disease clinically diagnosed as an autoimmune response acetylcholine receptor, which is shown below in action (from left or A rightarrow to right or C) Identify by name the lipid bilayer shown in A. Be specific. Identify by name the ion labeled with "?" in C. Identify the space or location in which the two acetylcholine molecules in B are located. Immediately after the event portrayed in C, which of the following is most likely to occur in the lipid bilayer shown in A? hyperpolarization depolarization repolarization no change In the space below, explain your answer in d).

Answer 1

6. (3 pts. each, except as indicated) Myasthenia gravis is an autoimmune disease clinically diagnosed as an autoimmune to the acetylcholine receptor, which is shown below in action (from left or A→ to right or C). response a) Identify by name the lipid bilayer shown in A. Be specific. phospholipid b) Identify by name the ion labeled with ..?" in C, sodium c) Identify the space or location in which the two acetylcholine molecules in B are located Nicotinic cholinergic receptors of neuromuscular junction (post synaptic region on motor end plate) d) Immediately after the event portrayed in C, which of the following is most likely to occur in the lipid bilayer,shown in A? hyperpolarization Mepolarization repolarization mo change (I5 pts) In the space below,explain your answer in )

Reason:

Myasthenia gravis (respiratory failure is a lethal complication): It is autoimmune disorder and a genetically inherited (from mother) disorder associated with imbalance muscular activity of both smooth muscle cells and skeletal muscles as predominantly due to blockade of acetylcholine receptors by host antibodies at the neuromuscular junction finally inhibiting excitatory postsynaptic (EPSPs) of acetylcholine neurotransmitter result in blockade of depolarization.

This effect is leading blockade of action potentials produced by the motor neuron electrical signals leading to low depolarization rising phase by acting on the cholinergic ligand-gated nicotinic receptors of the motor end plate, where there receptor proteins are located inside the mosaic of lipid layer of phospholipids.

Acetylcholine usually a fast ligand gated neurotransmitter which is released from the preganglionic and post ganglionic fibers of the parasympathetic nervous system further binds to the smooth and skeletal muscle cells. This binding takes place at neuromuscular junction synapse. Postsynaptically on the muscular motor endplate, acetylcholine binds to the “ligand gated nicotinic receptors” as well as it binds to “muscarinic acetyl choline receptors”.