Question

A team of researchers has conducted an exome sequencing study to find the causative mutation for a rare mendelian disease. All known cases have had an affected parent and it is likely that the disease is dominant. After comparing the exome sequences from four different patients, the researchers find that nine different genes have a potentially harmful mutation in all four patients under the dominant model. As expected no single mutation under the recessive model is shared by all four patients. What could the researchers do to reduce their set of nine potential genes to the single causative gene that they would expect for this Mendelian disease?

Answer 1

As per Gregor Mendal each gene accounts for certain morphological and physiological character expression. In order to get single causative gene for rare mendelian disease researchers need to identify all set of characters changes due to these nine mutated genes and then perform a cross breed experiment among those parents which are identified with mendelian disease. since the disease is dominant it will show it's full impact by crossover of same mutated gene dominantly and a single causative gene responsible for that particular trait will be found.