Question

A team of researchers has conducted an exome sequencing study to find the causative mutation for a rare mendelian disease. All known cases have had an affected parent and it is likely that the disease is dominant. After comparing the exome sequences from four different patients, the researchers find that nine different genes have a potentially harmful mutation in all four patients under the dominant model. As expected no single mutation under the recessive model is shared by all four patients.

What is the likely cause for the difference in the number of candidate genes under the dominant and recessive model?

Group of answer choices

a) Only one homologue needs to be sequenced to detect a dominant candidate mutation

b) There is a higher probability for inheriting a variant on both homologues of a gene independently

c) There is a higher probability for inheriting a variant on only one homologue of a gene

d) Dominant diseases are more common in human populations than recessive diseases

Answer 1

The disease is caused my some particular mutation. On performing studies, it is found out that the mutations fall under dominant model. Recessive model does not show any mutation. Recessive diseases are more common in a population than dominat diseases. There is also a higher probability for inheriting a variant on only one homologue of a gene.

Correct answer-C