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- Part A Regarding the strategy of peptide synthesis, which statement is true? o The N-terminal...
Amino acids are useful building blocks for peptide synthesis. However, due to several reactive sites, protecting...
Amino acids are useful building blocks for peptide synthesis. However, due to several reactive sites, protecting groups are used to direct regioselective synthesis. Below is the structure of an amino acid with a protecting group. H2N COOH Identify the protecting group. Which reagent was used to install this protecting group? Which reagent is used to remove this protecting group? Fmoc Benzyl chloroformate Boc 9-Fluorenylmethyl chloroformate amide 0 O O O TFA Piperidine DCC H2, Pd/C acetal Di-tert-butyl dicarbonate Acetic anhydride...
1. What is the purpose of “Boc anhydride,” (t-BUOCO)20, in the synthesis of polypeptides? O To...
1. What is the purpose of “Boc anhydride,” (t-BUOCO)20, in the synthesis of polypeptides? O To protect the amino nitrogen in the amino acid acting as electrophile. O To activate the amino nitrogen in the amino acid acting as nucleophile. O To activate the carboxylic acid (i.e., turn -OH into a good leaving group) in the amino acid acting as electrophile. O To protect the carboxylic acid in the amino acid acting as nucleophile. O To cleave the nitrogen protecting...
1st attempt Which process in solid-phase peptide synthesis is being depicted in Step 2 of the...
1st attempt Which process in solid-phase peptide synthesis is being depicted in Step 2 of the figure below? AAZ HH NCC Resin Nc DCC AAZ DCC Fmoc AA1 0 H H.N-C- Fmoc-Red DCC - Resin AA2 AA1 Repeat 18 times Fmoc-N- Fmoc AA20 АА HAN 2 E ct P20 ct & c- Resin 18 P1 Repeat 18 times Fmoc AA20 АМ CIN Iu- 10- Resin AA Amino AA2 Amino P acid 1 cd2 Protecting group 1 po Protecting o group...
- Use the structure of the peptide to complete the problems/questions following. O HONE CH- H-º-N...
- Use the structure of the peptide to complete the problems/questions following. O HONE CH- H-º-N CH-c o- CH2 CH-OH CH2 CH2 CH3 C=0 ΝΗ NH2 a. (4 pts) Name (full name) the N-terminal amino acid? b. (4 pts) Name (full name) the C-terminal amino acid? C. (5 pts) Using the 1 letter amino acid abbreviation, give the name of the peptide.
1. Given the following peptide, which of the following statements is true? Question options: a) The...
1. Given the following peptide, which of the following
statements is true?
Question options:
a) The N-terminal residue is leucine.
b)This peptide contains 4 amino acid residues.
c) The peptide contains a total of 6 ionizable groups.
d) The net charge of this peptide at pH 7 is +1 Locate any
peptide bond along the backbone of the given peptide.
e) The bond between the C (of the C=O) and the N (of the N-H) of
a peptide bond has...
PLEASE ANSWER ALL PARTS Part B Which of the following reactions would benefit the most from...
PLEASE ANSWER ALL PARTS
Part B Which of the following reactions would benefit the most from general-acid catalysis? View Available Hint(s) O the reaction of an acyl chloride with water O nucleophilic substitution of an alkyl halide by an amine O nucleophilic addition of water to an ester O nucleophilic substitution of an alkyl chloride by iodide O nucleophilic substitution of an alkyl chloride by water Submit Part E Which of the following is not a true statement? O A...
31. Which of the statement(s) regarding hydroboration is(are) true? I. The reaction with terminal olefins is...
31. Which of the statement(s) regarding hydroboration is(are) true? I. The reaction with terminal olefins is regioselective. II. It proceeds through a carbocation intermediate. II. It yields the Markovnikov product. IV. It proceeds through a cyclic transition state. V. The hydrogen on boron adds to the carbon with the most hydrogens already attached to it. VI. The first step is a Lewis acid-base reaction. VII. The boron predominantly adds to the least substituted carbon. 3 F. I, II, IV, and...
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use i...
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use in this lab is shown below Fmoc first amino acid linker a) (1 pt) If the resin has 0.72 mmol/g of this linker on the surface of the beads, and you use 300 mg of resin for the reaction, how many mmol of linker do you have? b) (3 pts) All peptides will use alanine at the C-tenminus (position 1), Fmoc-L-valine...
Indicate if the given statements are TRUE or FALSE regarding Hell Volhard Zelinski reaction 1. The...
Indicate if the given statements are TRUE or FALSE regarding Hell Volhard Zelinski reaction 1. The reaction involves nucleophilic acyl substitution as well as alpha substitution. II. Bra facilitates the formation of the acid bromide. III. Hell Volhard Zelinski can also be done using acetic acid as the catalyst. IV. Br2 acts as the electrophile in the a-bromination step. Propose a feasible synthesis for the following compound. The starting material is already given, you just need to supply the next...
use the notes provided to help answer the question above. will rate well The second step...
use the notes provided to help answer the question
above. will rate well
The second step of the synthesis transformation of the chlorosulfonyl functional group into a sulfonamide) is an example of a a. Nucleophilic displacement (substitution) b Elimination C. Electrophilic aromatic substitution d. Acid hydrolysis Esterification e. THE SULFONIC ACID GROUP AND ITS DERIVATIVES Sulfonic acids are organic analogs of sulfuric acid, a very strong acid. They are highly corrosive, react vigorously with water, and can cause skin bums....
Amino acids are useful building blocks for peptide synthesis. However, due to several reactive sites, protecting groups are used to direct regioselective synthesis. Below is the structure of an amino acid with a protecting group. H2N COOH Identify the protecting group. Which reagent was used to install this protecting group? Which reagent is used to remove this protecting group? Fmoc Benzyl chloroformate Boc 9-Fluorenylmethyl chloroformate amide 0 O O O TFA Piperidine DCC H2, Pd/C acetal Di-tert-butyl dicarbonate Acetic anhydride...
1. What is the purpose of “Boc anhydride,” (t-BUOCO)20, in the synthesis of polypeptides? O To protect the amino nitrogen in the amino acid acting as electrophile. O To activate the amino nitrogen in the amino acid acting as nucleophile. O To activate the carboxylic acid (i.e., turn -OH into a good leaving group) in the amino acid acting as electrophile. O To protect the carboxylic acid in the amino acid acting as nucleophile. O To cleave the nitrogen protecting...
1st attempt Which process in solid-phase peptide synthesis is being depicted in Step 2 of the figure below? AAZ HH NCC Resin Nc DCC AAZ DCC Fmoc AA1 0 H H.N-C- Fmoc-Red DCC - Resin AA2 AA1 Repeat 18 times Fmoc-N- Fmoc AA20 АА HAN 2 E ct P20 ct & c- Resin 18 P1 Repeat 18 times Fmoc AA20 АМ CIN Iu- 10- Resin AA Amino AA2 Amino P acid 1 cd2 Protecting group 1 po Protecting o group...
- Use the structure of the peptide to complete the problems/questions following. O HONE CH- H-º-N CH-c o- CH2 CH-OH CH2 CH2 CH3 C=0 ΝΗ NH2 a. (4 pts) Name (full name) the N-terminal amino acid? b. (4 pts) Name (full name) the C-terminal amino acid? C. (5 pts) Using the 1 letter amino acid abbreviation, give the name of the peptide.
1. Given the following peptide, which of the following
statements is true?
Question options:
a) The N-terminal residue is leucine.
b)This peptide contains 4 amino acid residues.
c) The peptide contains a total of 6 ionizable groups.
d) The net charge of this peptide at pH 7 is +1 Locate any
peptide bond along the backbone of the given peptide.
e) The bond between the C (of the C=O) and the N (of the N-H) of
a peptide bond has...
PLEASE ANSWER ALL PARTS
Part B Which of the following reactions would benefit the most from general-acid catalysis? View Available Hint(s) O the reaction of an acyl chloride with water O nucleophilic substitution of an alkyl halide by an amine O nucleophilic addition of water to an ester O nucleophilic substitution of an alkyl chloride by iodide O nucleophilic substitution of an alkyl chloride by water Submit Part E Which of the following is not a true statement? O A...
31. Which of the statement(s) regarding hydroboration is(are) true? I. The reaction with terminal olefins is regioselective. II. It proceeds through a carbocation intermediate. II. It yields the Markovnikov product. IV. It proceeds through a cyclic transition state. V. The hydrogen on boron adds to the carbon with the most hydrogens already attached to it. VI. The first step is a Lewis acid-base reaction. VII. The boron predominantly adds to the least substituted carbon. 3 F. I, II, IV, and...
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use in this lab is shown below Fmoc first amino acid linker a) (1 pt) If the resin has 0.72 mmol/g of this linker on the surface of the beads, and you use 300 mg of resin for the reaction, how many mmol of linker do you have? b) (3 pts) All peptides will use alanine at the C-tenminus (position 1), Fmoc-L-valine...
Indicate if the given statements are TRUE or FALSE regarding Hell Volhard Zelinski reaction 1. The reaction involves nucleophilic acyl substitution as well as alpha substitution. II. Bra facilitates the formation of the acid bromide. III. Hell Volhard Zelinski can also be done using acetic acid as the catalyst. IV. Br2 acts as the electrophile in the a-bromination step. Propose a feasible synthesis for the following compound. The starting material is already given, you just need to supply the next...
use the notes provided to help answer the question
above. will rate well
The second step of the synthesis transformation of the chlorosulfonyl functional group into a sulfonamide) is an example of a a. Nucleophilic displacement (substitution) b Elimination C. Electrophilic aromatic substitution d. Acid hydrolysis Esterification e. THE SULFONIC ACID GROUP AND ITS DERIVATIVES Sulfonic acids are organic analogs of sulfuric acid, a very strong acid. They are highly corrosive, react vigorously with water, and can cause skin bums....
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