A current therapy for cancer is an organic molecule that binds to the active site of...
A current therapy for cancer is an organic molecule that binds to the active site of Caspase-3. Describe the pathway that is inhibited by this drug and explain how this drug could help decrease the size of a tumor.
Homework Answers
Caspase 3 is an enzyme closely related to the apoptotic process, which is a major process involved in cancer development. Remember that evasion of apoptosis is closely related to cancer.
In few words we could say that a low or blocked caspase activity brings cancer and tumor growth, while a high/normal caspase activity prevents cancer, or reduces the size of a tumor. There are natural caspase inhibitors that work to avoid premature apoptosis in cells, but an overexpression of these inhibitors block apoptosis and lead to cancer development.
This current therapy mentioned then must be enhancing the caspase activity, it must work by activating the enzyme by attaching to it. The increased activity of caspase now can beggin to induce apoptosis in the tumoral cells, thus leading to decreasing tumor size
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A current therapy for cancer is an organic molecule that binds
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Pls give short answers. Thank you
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Please help with answers to these questions
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Reset Help noncompetitive enzyme irreversible acetylcholinesterase competitive active site 1. A inhibitor binds to a site on the enzyme that is not the active site. 2. Insecticides and nerve gases act as irreversible inhibitors of nerve conduction. an enzyme needed for 3. A inhibitor has a structure that is so similar to the substrate that it can bond to the enzyme just like the substrate. 4. Usually, an nhibitor forms a covalent bond with an amino acid side group within...
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Pls give short answers. Thank you
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answer questions
15) An apoenzyme + cofactor(s) - a) Inhibitor b) active site c) substrate d) holoenzyme 16) Aspartate-transcarbamylase is an enveloved in a pathway that may produces molecule called Cytidine triphosphate. Cytidine triphosphate can bind to anot t o this enzyme, rendering the active site nonfunctional. This is an example of a) ATP hydrolysis b) competitive inhibition c) feedback inhibition d) allosteric activation 17) Which of the following is false regarding fermentation? a) fermentation occurs in the absence of...
Please help with answers to these questions
answer the ones that are straightforward like this one
Question 24 5 pts 1. Beta-catenin is classified as a proto-oncogene and APC is classified as a tumor suppressor gene. Both are important parts of the Wnt signaling pathway. Describe the relationship between beta-catenin and APC. Explain in detail why they are classified as a proto-oncogene or tumor suppressor gene. 2. Suppose you're working in a cancer research lab and discover a small molecule...
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