Question

What is the metabolism phase 1 reactions that (acyclovir) can react? Write them all

NH2 ОН: -N NH N

Answer 1

Answer

Oxidation of primary alcohol

N 0 N NH N HO NH2
$\rightarrow$
N 0 1 H N NH NH2

Reduction of ketone

N 0 N NH N HO NH2
$\rightarrow$
OH N N NH N HO NH2

Hydrolysis of ether

N 0 N NH N HO NH2
$\rightarrow$
НЮ НО
and                                                                                                
OH N1 -N -OH NH N N2

Explanation

Metabolism phase I reactions include Oxidation, reduction and hydrolysis