Question

What are the metabolism ( phase 1 and phase 2 ) of chloroquine?

Answer 1

and to an ever lesser Chloscoquine is N-dealkylated pumasily by CYP2C8 CYP3A4 N- desethylchloroquine It is N-dealkylated to a lesser extent by CYP3A5 CYP2D6 , and to extent by CYPIAJ. N-desethylchloroquine can be further 1- dealkylated to N-bidesethylchloroquir which is further N- dealkylated to 4-chloro- 4 - aminoquinoline. N- Chloroquine V (R) - Chloroquine N- desethyl N - bidesethylchloroquine > 7- Chloro-4 -aminoquinoline