A 5 mL of a plasma sample containing an acidic drug was extracted with 10 mL...
A 5 mL of a plasma sample containing an acidic drug
was extracted with 10 mL of
chloroform. The total concentration of the drug in the aqueous
phase is 16 µg/mL. A total of
75% of the drug is ionized in the aqueous phase.
The concentration in the organic phase is
determined to be 7 µg/mL
(i) What is the concentration of the ionized and unionized drug in
the aqueous phase?[4 points]
(ii) Calculate the apparent partition coefficient (Papp) of this
drug? [10 points]
Homework Answers
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A 5 mL of a plasma sample containing an acidic drug
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5) A 100.0 mL aqueous solution containing 2.50 g of compound Z results is extracted with 25.0 mL of ethyl acetate. The ethyl acetate is evaporated to yield 0.95 g of compound Z. 4 points Calculate the partition coefficient (also known as the distribution coefficient) K, for compound Z in ethyl acetate and water, where K = (concentration of Z in diethyl ether) + (concentration of Z in water): Calculations Answer
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