Homework Answers
In this case, the Rho-family G protein are monomeric which means that they are composed by only one unit. Remember that a nonsense mutation occurs when a substitution of a single base pair produces a premature stop codon. So, if this occurs in a monomeric protein, only half of the G protein will be produced and it will lose its function.
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3. Is a nonsense mutation half-way through a Rho-family G protein more likely to result in...
Explain what classifies a mutation as “temperature‑sensitive” by comparing phenotype(s) with a wildtype allele. How is this type of phenotype explained by protein behaviour? Would the following typ...
Explain what classifies a mutation as “temperature‑sensitive” by comparing phenotype(s) with a wildtype allele. How is this type of phenotype explained by protein behaviour? Would the following types of mutations most likely have: severe effects, mild effects, or no effect on protein function? Briefly explain your answers. Note that there may be more than one correct answer, but you need only to give one sensible answer and explain your reasoning. [6 marks] A nonsense mutation occurring in sequences encoding amino...
Why is an insertion or deletion more likely to result in a damaging mutation than a...
Why is an insertion or deletion more likely to result in a damaging mutation than a point mutation? 1.Point mutations only change two or three nucleotides 2.Point mutations never change the amino acid that is called for in the protein 3.Insertions/deletions change all codons that follow them, unless they are indels of 3, 6, 9, etc 4.Point mutations cannot result in a stop codon, whereas insertions and deletions can.
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dyst...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dystrophin. The dystrophin protein itself is 3684 amino acids in length. Calculate below the approximate size of the mRNA that encodes dystrophin. Approximately what percentage of the gene that encodes dystrophin is intron sequence? The human genome encodes a much greater variety and number of proteins than the...
Do you expect a Pro→Gly mutation in a surface-loop region of a globular protein to be stabilizing or destabilizing? Assu...
Do you expect a Pro→Gly mutation in a surface-loop region of a
globular protein to be stabilizing or destabilizing? Assume the
mutant folds to a native-like conformation. Explain your answer in
terms of the predicted enthalpic and entropic
effects of the mutation on the ΔG for protein folding compared to
ΔG of folding for the wild-type protein.
Match the items in the left column to the appropriate blanks in
the sentences on the right.
ASsolvent Because the mutation is on...
Which of the following mutations are more likely to occur based on their codons, group classifica...
Which of the following mutations are more likely to occur based
on their codons, group classifications, and structures?
4) (20 points) Which of the following mutations are more likely to occur (aka more conservative) based on their codons (show the codons and underline anysingle nucleotide changes), group classifications, and structures (draw or describe the structures)? Circle or underline the mutation you believe is more conservative and explain your choices. BE SURE TO EXPLAIN WHY THE LESS CONSERVATIVE MUTATION IS LESS...
Match the following phenotypes with the mutation that would be the most likely to be its...
Match the following phenotypes with the mutation that would be the most likely to be its cause. The mutant proteins are listed below, followed by the protein domain that is mutated in each case, followed by the amino acid change that is a result of the mutation Try to answer each question by using the following reasoning: if you observe a phenotype, then that could be due to a mutation in protein in which the domain has had an amino...
Please answer 2-5 2. Consider a gene with a particular function. Mutation X and mutation Y...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
Review Questions BIOL 260: Chapters 8-10, 13, 19 1. Consider a mutation involving the deletion of...
Review Questions BIOL 260: Chapters 8-10, 13, 19 1. Consider a mutation involving the deletion of either 1, 2, or 3 nucleotides in the DNA of a bacterium. Which of these mutations (ie., deletion of 1, 2, or 3 nucleotides) would likely have the LEAST impact on the organism? Why? Include in your answer a comparison with the other two options to justify your reasoning. Think carefully about the impact each mutation would have on the ultimate protein coded for...
3. (8 pts) Use EVERY possible term to describe the mutational differences between the two sequences...
3. (8 pts) Use EVERY possible term to describe the mutational differences between the two sequences below (transition, transversion, point mutation, nucleotide substitution, deletion, insertion, frameshift mutation, nonsense, missense, synonymous, silent, non-synonymous.). There are many ways to describe each mutation. To get full points, use ALL the possible ways to describe each mutation from the list above. Mutations are in red at positions 09, 16, 23, and 35. 000 000 000 111 111 111 122 222 222 223 333 333...
You are consulting with a family where sometimes a mutation that leads to deafness (D) and...
You are consulting with a family where sometimes a mutation that leads to deafness (D) and a mutation that predisposes individuals to early heart failure (H) are linked. Normally these two traits sort independently but, in some individuals, a reciprocal translocation has moved them to the same chromosome. The chromosome maps for an individual with two normal chromosome pairs (Normal Arrangement), and a translocation heterozygote (Translocation Arrangement) are shown below. Deafness and early heart failure are both inherited in a...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dystrophin. The dystrophin protein itself is 3684 amino acids in length. Calculate below the approximate size of the mRNA that encodes dystrophin. Approximately what percentage of the gene that encodes dystrophin is intron sequence? The human genome encodes a much greater variety and number of proteins than the...
Do you expect a Pro→Gly mutation in a surface-loop region of a
globular protein to be stabilizing or destabilizing? Assume the
mutant folds to a native-like conformation. Explain your answer in
terms of the predicted enthalpic and entropic
effects of the mutation on the ΔG for protein folding compared to
ΔG of folding for the wild-type protein.
Match the items in the left column to the appropriate blanks in
the sentences on the right.
ASsolvent Because the mutation is on...
Which of the following mutations are more likely to occur based
on their codons, group classifications, and structures?
4) (20 points) Which of the following mutations are more likely to occur (aka more conservative) based on their codons (show the codons and underline anysingle nucleotide changes), group classifications, and structures (draw or describe the structures)? Circle or underline the mutation you believe is more conservative and explain your choices. BE SURE TO EXPLAIN WHY THE LESS CONSERVATIVE MUTATION IS LESS...
Match the following phenotypes with the mutation that would be the most likely to be its cause. The mutant proteins are listed below, followed by the protein domain that is mutated in each case, followed by the amino acid change that is a result of the mutation Try to answer each question by using the following reasoning: if you observe a phenotype, then that could be due to a mutation in protein in which the domain has had an amino...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
Review Questions BIOL 260: Chapters 8-10, 13, 19 1. Consider a mutation involving the deletion of either 1, 2, or 3 nucleotides in the DNA of a bacterium. Which of these mutations (ie., deletion of 1, 2, or 3 nucleotides) would likely have the LEAST impact on the organism? Why? Include in your answer a comparison with the other two options to justify your reasoning. Think carefully about the impact each mutation would have on the ultimate protein coded for...
3. (8 pts) Use EVERY possible term to describe the mutational differences between the two sequences below (transition, transversion, point mutation, nucleotide substitution, deletion, insertion, frameshift mutation, nonsense, missense, synonymous, silent, non-synonymous.). There are many ways to describe each mutation. To get full points, use ALL the possible ways to describe each mutation from the list above. Mutations are in red at positions 09, 16, 23, and 35. 000 000 000 111 111 111 122 222 222 223 333 333...
You are consulting with a family where sometimes a mutation that leads to deafness (D) and a mutation that predisposes individuals to early heart failure (H) are linked. Normally these two traits sort independently but, in some individuals, a reciprocal translocation has moved them to the same chromosome. The chromosome maps for an individual with two normal chromosome pairs (Normal Arrangement), and a translocation heterozygote (Translocation Arrangement) are shown below. Deafness and early heart failure are both inherited in a...
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