1. Identify the most acidic proton on each of the molecules shown below. (8 pts.) Но....
1. Identify the most acidic proton in each molecule. Briefly explain your reasoning based on structure (stating the pKa value is not enough, here. You must bring in factors related to ARIO). OH HACO NO2
For each of the following pairs of molecules, indicate the
compound containing the most acidic nitrogen atom
For each of the following pairs of molecules, indicate the compound containing the most acidic proton 3 pts Vs Br HO HO A VS B HACO D Pair 1: (Select) Pair 2: [ Select)
For each group of molecules below, rank the molecules from most
to least acidic (1 as most acidic). Explain why.
A)
B)
O: O: O:
For each of the following pairs of molecules, indicate the compound containing the most acidic proton o Br VS HO HO H VS H3CO А B D < Pair 1: [Select ] Pair 2: Select)
2. Identify the most acidic proton in each molecule below. Explain your reasoning. A. в.о C. 3. Four phenolic acids are presented below (A-D). Predict the relative acidity (strongest to weakest acid) o
Consider the indicated protons in the molecules shown below. Circle the molecule with the lower pK, and explain your choice with an appropriate drawing. NH ZE OH оме Но, . Meo b) Ho Ho (Rationalize with a one sentence explanation.) d) Rank the following molecules in order from least acidic to most acidic. Rationalize your choice with an appropriate drawing.
For each molecule below, predict the most acidic proton. Explain your answer in each case.
3. Identify the relationship between the pairs of molecules shown below as either: the same molecule, diastereomers, enantiomers, or epimers. (3 points each) CH2OH СНОн он но -н H-OH он OH он OH OH OH H2OH CH2OH 4. Draw the Line Angle formula for the products of the following reactions. (4 points each) Cu+2 -Cu2O(s) + + но -н CH2OH Ht, heat OH HO heat
8. Circle the most acidic one among the hydrogens shown in each molecule below.
1) Draw the conjugate base of each acid by deprotonation of the
most acidic proton (might not be shown).
2) Rank the following acids from weakest to strongest (1=weakest
6=strongest)
ОН (А) ГОН "NH₂