Question

Practice Problem 5 Part B What is the probability that Hank and Hazel's male offspring will be a carrier of PFK deficiency? Hazel's breeder has confirmed that she is not a carrier of PFK deficiency 0 0% 25% ОООО 50% 75% 100% Submit Request Answer Part What is the probability that Howey and Hailey's unaltected female offspring will be carriers of PFK deficiency? 0 0 259 SON 67 75 Submit Requests Part D Complete previous parts)

Answer 1

Answer:

$\rightarrow$Part B:-

• Given that cross is with Hazel and Hank.
• PFK is a autosomal rcessive disorder.
• Let P be the normal allele and 'p' be the mutant allele. it is said that Hazel is not a carrier of 'p' allele.
• That means she is homozygous dominant (PP).
• The genotype or information regarding the Haze is not provided in the question, so there is a possibility for him to be PP / Pp / pp.

Case 1 -

parents-- genotype -- PP (Hazel) x PP (Hank)

gametes-- P P

cross -- PP - all PP as no 'p' allele, so % of carriers = 0

Case 2 -

parents-- genotype-- PP (Hazel) x Pp(Hank)

gametes-- P P, p

cross--

	P
P	PP - normal
p	Pp - carrier

Hence % of carriers = 50%

Case 3 -

parents-- genotype-- PP(Hazel) x pp (Hank)

gametes-- P p

cross-- Pp - 100% carriers.

$\rightarrow$Part C:

• We know that Hazel is PP. and it is asked in the question that what is the probability that their unaffected girl child is a carrier.
• To be unaffected there are two possible genotypes - either two be PP or Pp.

So, chance of girl child to be carrier = chance of Pp / total chances possible = 1/2

= 50%

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