Question

If antibodies resulting from somatic hypermutation followed by affinity maturation, mutations _____________.(select all that apply.). a)...

If antibodies resulting from somatic hypermutation followed by affinity maturation, mutations _____________.(select all that apply.).

a) affect immunoglobulin and other B-cell genes

b)are present at a much greater frequency than would be generated by the typical spontaneous mutation rate.

c) are concentrated at nucleotide positions encoding CDR loops that make up antigen-binding sites.

d) are present randomly throughout the variable regions in heavy- and light-chain genes.

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a) affect immunoglobulin and other B-cell genes.

d) are present randomly throughout the variable regions in heavy- and light-chain genes.

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