In antibodies resulting from somatic hypermutation followed by affinity maturation, mutations ______________________________. (Select all that apply.)...

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Question

In antibodies resulting from somatic hypermutation followed by affinity maturation, mutations ______________________________. (Select all that apply.)...

In antibodies resulting from somatic hypermutation followed by affinity maturation, mutations ______________________________. (Select all that apply.)

Group of answer choices

A. affect immunoglobulin and other B-cell genes

B. are present at a much greater frequency than would be generated by the typical spontaneous mutation rate

C. are present randomly throughout the variable regions in heavy- and light-chain genes

D. are concentrated at nucleotide positions encoding CDR loops that make up antigen-binding sites

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Answer 1

Answer #1

The correct answers are-

B. are present at a much greater frequency than would be generated by the typical spontaneous mutation rate

C. are present randomly throughout the variable regions in heavy- and light-chain genes

This is because somatic hypermutation is a process wherein point mutations accumulate in the antibody in the variable regions of both the heavy and light chains. These are at rates that are about 10⁶-fold higher than the background mutation rates observed in other genes

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Answer 2

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In antibodies resulting from somatic hypermutation followed by affinity maturation, mutations ______________________________. (Select all that apply.)...

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