Question

Question 6 1 pts While the Rag1/2 complex mediates the initial cleavage of the recombination signal sequences during VDJ recombination, other enzymes are needed to join the cut regions together. Beyond defects in V(DJ recombination, what other defect might you observe in cells lacking one or more of these other enzymes? Defective RNA processing Defective repair of DNA double strand breaks Defective histone methyltransferase function Defective repair of thymidine dimers

Answer 1

Defective repair of double strand breaks.

It is because cleavage leads to double strand break which has to with the help of double strand break repair enzyme like ku70, ku86, DNA-PKCs, ligase IV, artemis, and XRCC4. Lacking these machines cell would be more sensetive to the radiation ionization and severe immunodificient.