Question

Draw three separate oxygen-hemoglobin dissociation curves and then use arrows to show the change in oxygen saturation of most hemoglobins when:

1. deoxygenated blood enters the capillaries in the lungs.
2. oxygenated blood enters the capillaries in muscle tissue at rest.
3. oxygenated blood enters the capillaries in muscle tissue during vigorous exercise.

Answer 1

The answers are given in sequence:

Normal O, Hb dissociation Curve 1 % Saturation of Hb Og Hb dissociation Curve when deoxygenated blood enters the capillaries in lings. 20 100 40 60 PO2 Explanation In the capillaries of lungs poz ú increased. As increased PO 2 more oxygen binds to the Hemoglobino So, a left shift is seen in O2-Hb dissociation curve. 2. Normal O, Hb dissociation Curve Right Shift % Saturcation of Hb Oz Hb dissociation Curve in muscle tissue at rest. 20 40 CO 100 80 pO2 → Explanation: CO₂ from the muscle tissue reaches the nearest capillaries As, blood enteres the capillarcies, it faces increase in pCO2. As pCO2 is increased, affinity for oxygen of the hemoglobin gets decreased. So, dissociation of Oxyhemoglobin occures and gradually the curve shifts to right.

Normal O₂ Hb dissocial Curve Right shift % Saturation of Hb 2 Hb dissociation curve in muscle tissue during vigorous exercise 20 40 SO 100 PO2 exercise During vigorous exercise there is increased production of cog. So, pCoz is increased. Also theree ů increased consumption of O2. So, plg is decreased. And during vigorous & temperaturce is increasedo Sog ↑ CO2, I pO2 and a temperature causes right shift of Oz Hb dissociation cureve. * factors affecting * factors effecting Right shift: p pCO2, temp, & pH, d PO2 Lett shift: Apoq, ditemp, tpH, & PCO2. [In In no. 3 more right shitt is observed due to excess production of co₂ and rise in temperaturce