Question

Currently proteinase-activated receptors have been demonstrated to be involved in a number of important disease processes. Which of the following disease processes have been implicated?

Select one:

a. clotting disorders, colitis and glaucoma

b. glaucoma, inflammatory bowel disease and atherosclerosis

c. inflammatory bowel disease, glaucoma and colitis

d. atherosclerosis, inflammatory bowel disease and colitis

e. atherosclerosis, clotting disorders and glaucoma

Answer 1

Answer:-

b. glaucoma , inflammatory bowel disease and atherosclerosis

c. inflammatory bowel disease , glaucoma and colitis

d. atherosclerosis, inflammatory bowel disease and colitis

Protease activated receptors (PARs) belong to the G protein coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands able to induce their activation. Indeed, PARs are physiologically activated after proteolytic clevage of their N-terminal domain by proteases. The resulting N- terminal end becomes a tethered activation ligand that interact with the extracellular loop 2 domain and thus induce PAR signal. PARs expression is ubiquitous and these receptors have been largely described in chronic inflammatory diseases and cancer.