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Describe the sliding filament hypothesis of muscle contraction.

Describe the sliding filament hypothesis of muscle contraction.

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Answer #1

The steps of sliding filament theory of muscle contraction are as follows -

1. In the resting phase, myosin head is bound to ADP and inorganic phosphate. This is high energy configuration. This whole assembly is bound to actin filament.

2. The myosin head bands and pulls the actin filament towards the M line. This leads to release of ADP and inorganic phosphate.

3. A new ATP molecule comes and bind to the myosin head. This is low energy configuration. At this stage, the actin filament and myosin head are dissociated from each other.

4. The bound ATP molecule again splits into ADP and inorganic phosphate. This cocks the myosin head.

5. Again the myosin is bound to ADP and inorganic phosphate and to actin filament. This is high energy configuration and the cycle repeats again.

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