Question

27. Integrins are single-pass integral membrane proteins in the plasma membrane of animal cells and are involved in the interaction of the cell with the surrounding extracellular matrix. Which of the following descriptions do you think matches the transmembrane part of an integrin molecule? A. It forms a B barrel. B. It is an a helix that is bent in the middle. C. It is about 10 amino acids long, with every other amino acid side chain being hydrophobic. D. It folds in a conformation with maximal intrachain hydrogen-bonding. E. It is about 100 amino acids long.

Answer 1

27% The size varies but typically the a- and B-subumis contain around 1000 and 750 amino acids, respectively. The part of the protein that is embedded in the hydrophobic regions of the bilayer are alpha helical and composed of predominantly hydrophobic amino acids. Since most residues in helices are involved in short-range infra- chain contacts. So, the correer answer here is option D ->IC folds m a conformation with maximal improchaios hydrogen-bonding. Scanned with CamScanner