Question

Predict the major product of the following reaction: HN AICl3 CI NH HN HN HN O A O B O C O D O E no reaction

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Answer #1

Here, no reaction occurs.

Explanation: -NHCOCH2CH3 group present on benzene ring becomes highly deactivating group in presence of Lewis acid, AlCl3. The deactivating group on benzene ring withdraws electron density on benzene ring and decreases the electron density on benzene ring so Friedel-Craft's alkylation do not occur. So here, no reaction occurs.

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