Question

How does Hemoglobin (Hb) bind oxygen with high affinity in the lungs, and then releases about a third of it in the tissues? How the affinity of hemoglobin to oxygen change when hemoglobin is in the lungs compared to when it is in the tissues? What factors influence the affinity of hemoglobin to oxygen and how?

Answer 1

Hemoglobin is a protein in purple blood cells (RBCs) that consists of oxygen. Almost 30%,percent of the mass of RBCs is made up via hemoglobin. This lets in RBCs to carry a lot greater oxygen than should in any other case be dissolved into blood.
A researcher research the oxygen dissociation curves of everyday grownup hemoglobin (HbA), fetal hemoglobin (HbF), and myoglobin (Mb), a associated compound. He dissolves samples of each protein in a cup of water, and locations each cup in a sealed canister in contact with a fuel. He modifications the partial strain of oxygen P O_2 inside the gasoline. For each measured P O_2
start textual content, P, area, O, give up textual content, start subscript, 2, give up subscript, he measures the saturation of oxygen within the proteins in the fluid. The saturation is the share of general binding sites on the HbA, HbF, or Mb, that are bound to oxygen. The results are proven below.

rayoglobine Hemoglobi Hemoglobin HOA) (mm Hg) ( POL)

There are numerous crucial elements that have an effect on the affinity of hemoglobin to oxygen as therefore have an effect on the oxygen-hemoglobin dissociation curve. These elements include the (1) pH (2) temperature (3) carbon dioxide (4) 2,3-BPG and (five) carbon monoxide