Question

In a synapse the presence of acetylcholine is a signal. Where does the acetylcholine come from? When is acetylcholine released? Why is acetylcholine released? How is acetylcholine released? How is the signal turned off?

Answer 1

Bocerylcholine in sipathesized in certain - neuron by the enzyme choline acetyltransferare – from the compounds choline and acetyl con in the agosol a the presynaphic aron teominal and stooed in synaptic vesces. so released by presynaptie axon terminal motoo neurons at neuromuscularo Jurictions CNMG) when a motoo neuron gamesaites a action potential, ut travels rapidly along the neare until it reaches the NmT, whez int initiates on electrochemical process that causes acetylcholine to be released into the раар арасе mimature and plate potentials in response to action potentials at NMJ are due to release of packets of acetylcholine from storage vesicles that finally produce on CNS - support cognitive functions - gn PNS muscle contraction - + t Nerve impuere promotes una vesicular and axonal momboanes through taxonal cat entry which fluidizes. e membrane el contents 8 vesicles enzymes, transmitter and other protons) are

$0$ | Page No Date - -- of extruded by exocytosis in junctional - - - - ______- ---- action a acetylcholine is teominated by degradation by an enzyme acetys cholinesterase that is in the synaptic cleft. Acetylcholine cholinesterase in scetul Choline & acetate Engene binds to the occylcholine and breaks it apart so that the acetylcholine can no longeo fit into receptoo on prol postsynaptic an te membranes.. -- - - -