Where does the Corynebacterium diphtheria toxin come from and how is its expression regulated? Should the expression be on or off in a host and why?
Answer: The toxin producing gene (tox gene) is carried by the beta bacteriophages which affects the Corynebacterium. The expression of the gene is controlled by the genome of the Corynebacterium, an iron activated repressor system called DTxR protein. In the presence of iron, the DTxR will be activated and bind to the promoter of tox gene thereby preventing the transcription of the toxin gene. If the iron is not there, the DTxR in the host will be deactivated and the tox gene will be derepressed and the transcription of the toxin gene will be activated. So in the host Corynebacterium the DTxR expression should be on in order to repress the tox gene.
Where does the Corynebacterium diphtheria toxin come from and how is its expression regulated? Should the...
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